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CYCS cytochrome c, somatic [ Equus caballus (horse) ]

Gene ID: 100053958, updated on 10-Feb-2026
Official Symbol
CYCSprovided by VGNC
Official Full Name
cytochrome c, somaticprovided by VGNC
Primary source
VGNC:VGNC:50468
See related
Ensembl:ENSECAG00000014330
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
all
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See CYCS in Genome Data Viewer
Location:
chromosome: 4
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_12 current TB-T2T (GCF_041296265.1) 4 NC_091687.1 (60669137..60671398, complement)
RS_2024_08 previous assembly EquCab3.0 (GCF_002863925.1) 4 NC_009147.3 (56623139..56625670, complement)

Chromosome 4 - NC_091687.1Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein like 3 Neighboring gene uncharacterized LOC138923958 Neighboring gene uncharacterized LOC106783078 Neighboring gene sperm microtubule inner protein 4 Neighboring gene neuropeptide VF precursor

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Thoroughbred Stallion gene expression
  • BioProject: PRJEB53382
  • Analysis date: Mon Jan 06 09:53:19 2025

Related articles in PubMed

  1. Crystallization and preliminary X-ray analysis of dimeric and trimeric cytochromes c from horse heart. Taketa M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Nov 1. PMID 21045299, Free PMC Article
  2. Ferricytochrome (c) directly oxidizes aminoacetone to methylglyoxal, a catabolite accumulated in carbonyl stress. Sartori A, et al. PLoS One, 2013. PMID 23483930, Free PMC Article
  3. Mutant Cytochrome C as a Potential Detector of Superoxide Generation: Effect of Mutations on the Function and Properties. Chertkova RV, et al. Cells, 2023 Sep 19. PMID 37759538, Free PMC Article
  4. Interaction of dimeric horse cytochrome c with cyanide ion. Nugraheni AD, et al. J Biol Inorg Chem, 2013 Mar. PMID 23412550
  5. The (not completely irreversible) population of a misfolded state of cytochrome c under folding conditions. Soffer JB, et al. Biochemistry, 2013 Feb 26. PMID 23368898

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutant Cytochrome C as a Potential Detector of Superoxide Generation: Effect of Mutations on the Function and Properties.
    Title: Mutant Cytochrome C as a Potential Detector of Superoxide Generation: Effect of Mutations on the Function and Properties.
  2. Kinetics and Energetics of Intramolecular Electron Transfer in Single-Point Labeled TUPS-Cytochrome c Derivatives.
    Title: Kinetics and Energetics of Intramolecular Electron Transfer in Single-Point Labeled TUPS-Cytochrome c Derivatives.
  3. Lysine 72 substitutions differently affect lipid membrane permeabilizing and proapoptotic activities of horse heart cytochrome c.
    Title: Lysine 72 substitutions differently affect lipid membrane permeabilizing and proapoptotic activities of horse heart cytochrome c.
  4. Unraveling cardiolipin-induced conformational change of cytochrome c through H/D exchange mass spectrometry and quartz crystal microbalance.
    Title: Unraveling cardiolipin-induced conformational change of cytochrome c through H/D exchange mass spectrometry and quartz crystal microbalance.
  5. Anion-Specific Effects on the Alkaline State of Cytochrome c.
    Title: Anion-Specific Effects on the Alkaline State of Cytochrome c.
  6. The Puzzling Problem of Cardiolipin Membrane-Cytochrome c Interactions: A Combined Infrared and Fluorescence Study.
    Title: The Puzzling Problem of Cardiolipin Membrane-Cytochrome c Interactions: A Combined Infrared and Fluorescence Study.
  7. Effect of Antioxidants on Heavy Metals Induced Conformational Alteration of Cytochrome C and Myoglobin.
    Title: Effect of Antioxidants on Heavy Metals Induced Conformational Alteration of Cytochrome C and Myoglobin.
  8. Negative surface charges in neuroglobin modulate the interaction with cytochrome c.
    Title: Negative surface charges in neuroglobin modulate the interaction with cytochrome c.
  9. The conformational dynamics of Cyt c in the presence of cardiolipin (CL) and phosphatidylcholine (PC) phospholipids was studied.
    Title: Impact of Cardiolipin and Phosphatidylcholine Interactions on the Conformational Ensemble of Cytochrome c.
  10. This work applies a combined experimental and computational study of Cyt c variants to assess whether the parameters that regulate the canonical electron transport function of Cyt c are correlated with those that determine the transition to alternative conformations, using the alkaline transition as a model conformational change.
    Title: Electron transfer and conformational transitions of cytochrome c are modulated by the same dynamical features.
Submit: New GeneRIF Correction See all GeneRIFs (45)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables electron transfer activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cytochrome c
Names
cytochrome c-like protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164014.2 → NP_001157486.2  cytochrome c

    Status: PROVISIONAL

    Source sequence(s)
    JBFNWK010000004
    UniProtKB/Swiss-Prot
    P00004
    UniProtKB/TrEMBL
    K9KAT1, L7MRG1

RefSeqs of Annotated Genomes: GCF_041296265.1-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference TB-T2T Primary Assembly

Genomic

  1. NC_091687.1 Reference TB-T2T Primary Assembly

    Range
    60669137..60671398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005609174.4 → XP_005609231.2  cytochrome c isoform X1

    UniProtKB/Swiss-Prot
    P00004
    UniProtKB/TrEMBL
    K9KAT1, L7MRG1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00004.2 GenPept UniProtKB/Swiss-Prot:P00004

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials