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MBTPS2 membrane bound transcription factor peptidase, site 2 [ Equus caballus (horse) ]

Gene ID: 100051796, updated on 4-Feb-2026
Official Symbol
MBTPS2provided by VGNC
Official Full Name
membrane bound transcription factor peptidase, site 2provided by VGNC
Primary source
VGNC:VGNC:20019
See related
Ensembl:ENSECAG00000000437
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
all
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Try the new Transcripts and proteins table
See MBTPS2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_12 current TB-T2T (GCF_041296265.1) X NC_091715.1 (17014431..17056714)
RS_2024_08 previous assembly EquCab3.0 (GCF_002863925.1) X NC_009175.3 (17255391..17297613)

Chromosome X - NC_091715.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106781346 Neighboring gene small muscle protein X-linked Neighboring gene spermine synthase Neighboring gene phosphate regulating endopeptidase X-linked

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Thoroughbred Stallion gene expression
  • BioProject: PRJEB53382
  • Analysis date: Mon Jan 06 09:53:19 2025

Related articles in PubMed

  1. An Intronic MBTPS2 Variant Results in a Splicing Defect in Horses with Brindle Coat Texture. Murgiano L, et al. G3 (Bethesda), 2016 Sep 8. PMID 27449517, Free PMC Article
  2. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in membrane protein intracellular domain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of PcG protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
membrane-bound transcription factor site-2 protease
Names
Membrane-bound transcription factor site-2 protease-like protein

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_041296265.1-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference TB-T2T Primary Assembly

Genomic

  1. NC_091715.1 Reference TB-T2T Primary Assembly

    Range
    17014431..17056714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023634090.2 → XP_023489858.1  membrane-bound transcription factor site-2 protease isoform X2

    UniProtKB/TrEMBL
    A0A9L0RC10, F7C6B1
    Related
    ENSECAP00000060027.1
    Conserved Domains (2) summary
    cd06162
    Location:14 → 230
    S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
    pfam02163
    Location:160 → 501
    Peptidase_M50; Peptidase family M50

  2. XM_023634091.2 → XP_023489859.1  membrane-bound transcription factor site-2 protease isoform X3

    UniProtKB/TrEMBL
    A0A3Q2HC35
    Conserved Domains (2) summary
    cd06162
    Location:14 → 230
    S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
    pfam02163
    Location:160 → 304
    Peptidase_M50; Peptidase family M50

  3. XM_070257237.1 → XP_070113338.1  membrane-bound transcription factor site-2 protease isoform X4

    UniProtKB/TrEMBL
    A0A3Q2HC35

  4. XM_023634089.2 → XP_023489857.1  membrane-bound transcription factor site-2 protease isoform X1

    UniProtKB/TrEMBL
    A0A9L0R457
    Related
    ENSECAP00000056510.1
    Conserved Domains (3) summary
    cd06162
    Location:14 → 224
    S2P-M50_PDZ_SREBP; Sterol regulatory element-binding protein (SREBP) Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50A), regulates intramembrane proteolysis (RIP) of SREBP and is part of a signal transduction mechanism involved in sterol and lipid ...
    COG5048
    Location:487 → 575
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:489 → 509
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_070257238.1 → XP_070113339.1  membrane-bound transcription factor site-2 protease isoform X5

RNA

  1. XR_002805511.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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