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PLCB1 phospholipase C beta 1 [ Equus caballus (horse) ]

Gene ID: 100051558, updated on 8-Mar-2024

Summary

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Official Symbol
PLCB1provided by VGNC
Official Full Name
phospholipase C beta 1provided by VGNC
Primary source
VGNC:VGNC:21535
See related
Ensembl:ENSECAG00000021224
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
33
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 22 NC_009165.3 (15084830..15753422, complement)
102 previous assembly EquCab2.0 (GCF_000002305.2) 22 NC_009165.2 (14866149..15316997, complement)

Chromosome 22 - NC_009165.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111769959 Neighboring gene lysosomal associated membrane protein family member 5 Neighboring gene phospholipase C beta 4 Neighboring gene U6 spliceosomal RNA Neighboring gene thioredoxin related transmembrane protein 4 Neighboring gene hydroxyacid oxidase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Names
phospholipase C, beta 1 (phosphoinositide-specific)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009165.3 Reference EquCab3.0 Primary Assembly

    Range
    15084830..15753422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023626130.1 → XP_023481898.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A5F5PV51, F6T8C1
    Related
    ENSECAP00000018741.3, ENSECAT00000022663.4
    Conserved Domains (5) summary
    cd00275
    Location:677 → 796
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:316 → 643
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:22 → 148
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16208
    Location:153 → 303
    EFh_PI-PLCbeta1; EF-hand motif found in phosphoinositide phospholipase C beta 1 (PI-PLC-beta1)
    pfam08703
    Location:1003 → 1172
    PLC-beta_C; PLC-beta C terminal

  2. XM_023626131.1 → XP_023481899.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A5F5PV51
    Conserved Domains (5) summary
    cd00275
    Location:677 → 796
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08591
    Location:316 → 643
    PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
    cd13361
    Location:22 → 148
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    cd16208
    Location:153 → 303
    EFh_PI-PLCbeta1; EF-hand motif found in phosphoinositide phospholipase C beta 1 (PI-PLC-beta1)
    pfam08703
    Location:1003 → 1141
    PLC-beta_C; PLC-beta C terminal
Nucleotide Protein
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