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GNAS GNAS complex locus [ Sus scrofa (pig) ]

Gene ID: 100049657, updated on 4-Apr-2024

Summary

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Official Symbol
GNASprovided by VGNC
Official Full Name
GNAS complex locusprovided by VGNC
Primary source
VGNC:VGNC:110580
See related
Ensembl:ENSSSCG00000007520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
SCG6; NESP55; PORGSA1
Expression
Ubiquitous expression in ovary (RPKM 105.8), kidney (RPKM 105.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
20
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 17 NC_010459.5 (58985580..59053022)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 17 NC_010459.4 (66303970..66356738) , (66408660..66423431)

Chromosome 17 - NC_010459.5Genomic Context describing neighboring genes Neighboring gene aminopeptidase like 1 Neighboring gene microRNA mir-296 Neighboring gene uncharacterized LOC110257458 Neighboring gene uncharacterized LOC106506736 Neighboring gene negative elongation factor complex member C/D Neighboring gene cathepsin Z

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression analysis of the GNAS gene in pig and porcine fibroblast cells. Peng J, et al. Genet Mol Res, 2014 Jul 24. PMID 25078603
  2. Genetic suppression of Gαs protein provides rate control in atrial fibrillation. Lugenbiel P, et al. Basic Res Cardiol, 2012 May. PMID 22457123
  3. Expression and imprinting analysis of the NESP55 gene in pigs. Oczkowicz M, et al. Gene Expr Patterns, 2012 Jan-Feb. PMID 22067442
  4. Meiotic resumption of porcine immature oocytes is prevented by ooplasmic Gsalpha functions. Morikawa M, et al. J Reprod Dev, 2007 Dec. PMID 17693700
  5. The GNAS Locus: Quintessential Complex Gene Encoding Gsalpha, XLalphas, and other Imprinted Transcripts. Bastepe M. Curr Genomics, 2007 Sep. PMID 19412439, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Galphas and Galphaq peptides adopt different orientations in beta2-AR and V1AR, respectively. The beta2-AR/Galphas peptide interface is dominated by electrostatic interactions, whereas the V1AR/Galphaq peptide interactions are predominantly hydrophobic.
    Title: Structural Elements in the Gαs and Gαq C Termini That Mediate Selective G Protein-coupled Receptor (GPCR) Signaling.
  2. Target RNA interference of GNAS in porcine fibroblast cells leads to lower mRNA expression of Bcl-2, Fas, and Caspase-3, which are recognized as apoptosis related markers.
    Title: Molecular cloning and expression analysis of the GNAS gene in pig and porcine fibroblast cells.
  3. study did not find any significant associations for polymorphisms in insulin-like grwoth factor 2, GTP Binding Protein alpha Subunits, Gs and melanocortin receptor 4 genes with reproductive traits of Polish Landrace and Large White pigs
    Title: Lack of the associations of the polymorphisms in IGF2, MC4R and GNAS genes with reproduction traits in pigs and imprinting analysis of IGF2 gene in ovary and cornus uteri.
  4. Genetic inhibition of GNAS protein in the atrioventricular node reduced heart rate and prevented atrial fibrillation-associated reduction of cardiac function in a porcine model.
    Title: Genetic suppression of Gαs protein provides rate control in atrial fibrillation.
  5. Imprinting analysis showed that NESP55 is maternally expressed in young and adult pigs.
    Title: Expression and imprinting analysis of the NESP55 gene in pigs.
  6. meiotic resumption of porcine oocytes is prevented by ooplasmic Gsalpha, which may stimulate cAMP synthesis within porcine oocytes
    Title: Meiotic resumption of porcine immature oocytes is prevented by ooplasmic Gsalpha functions.
  7. Review article on the human GNAS complex locus.
    Title: The GNAS Locus: Quintessential Complex Gene Encoding Gsalpha, XLalphas, and other Imprinted Transcripts.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables D1 dopamine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables beta-2 adrenergic receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables corticotropin-releasing hormone receptor 1 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables insulin-like growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mu-type opioid receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to parathyroid hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sensory perception of chemical stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of heterotrimeric G-protein complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide-binding protein G(s) subunit alpha; SCG6 (secretogranin VI)
Names
adenylate cyclase-stimulating G alpha protein
alpha-stimulatory subunit of GTP-binding protein
guanine nucleotide-binding protein G(s), alpha subunit
guanine nucleotide-binding protein, alpha-stimulating activity polypeptide 1
secretogranin VI

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130215.2 → NP_001123687.1  SCG6 (secretogranin VI) isoform SCG6

    See identical proteins and their annotated locations for NP_001123687.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) is maternally expressed and encodes neuroendocrine secretory protein 55 (NESP55), which localizes to large secretory vesicles of endocrine cells and neurons. Its coding region is within the 5'-most exon and does not overlap the coding regions used by other transcripts; thus NESP55 has no similarity to isoforms of the G-protein alpha subunit. This variant has an antisense transcript, GNASAS.
    Source sequence(s)
    AK237491, AK238881, EW249893, EW485651, FS704770, FS707689, FS709946
    UniProtKB/TrEMBL
    A0A4X1URQ7, A0A8D1IPH8, A5GFT7
    Conserved Domains (1) summary
    pfam06390
    Location:1 → 250
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

  2. NM_001171983.2 → NP_001165454.1  guanine nucleotide-binding protein G(s) subunit alpha isoform GNASS

    See identical proteins and their annotated locations for NP_001165454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) is biallelically expressed. It lacks an internal exon and uses an alternate splice site, compared to variant 1. It encodes isoform GNASS, also known as alpha-S1, which differs in an internal region and has identical N- and C-termini, compared to isoform GNASL.
    Source sequence(s)
    AK233105, AK238560, DV937277, EW485651, FS668911, FS710845
    UniProtKB/TrEMBL
    A0A480UPA5, A0A8D1PSG6
    Conserved Domains (1) summary
    cd00066
    Location:41 → 374
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  3. NM_001171984.2 → NP_001165455.1  guanine nucleotide-binding protein G(s) subunit alpha isoform f

    See identical proteins and their annotated locations for NP_001165455.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) is biallelically expressed and uses an alternate splice site, compared to variant 1. It encodes isoform f which is one aa longer than isoform GNASL.
    Source sequence(s)
    AK238560, AK240484, DV937277, EW485651, FS668911, FS710845
    UniProtKB/TrEMBL
    A0A4X1URN3, A0A4X1UVC6, A0A5G2QYC4, A5GFU7
    Related
    ENSSSCP00000030735.1, ENSSSCT00000035487.2
    Conserved Domains (1) summary
    cd00066
    Location:41 → 389
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  4. NM_001171985.2 → NP_001165456.1  guanine nucleotide-binding protein G(s) subunit alpha isoform g

    See identical proteins and their annotated locations for NP_001165456.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) is biallelically expressed and lacks an internal exon, compared to variant 1. It encodes isoform g, which lacks an internal segment, compared to isoform GNASL.
    Source sequence(s)
    AK238881, AK240484, DV937277, EW485651, FS668911, FS710845
    UniProtKB/TrEMBL
    A0A4X1UWE8, A0A8D1PSG6, A5GFU6
    Related
    ENSSSCP00000075806.1, ENSSSCT00000095600.1
    Conserved Domains (1) summary
    cd00066
    Location:41 → 373
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  5. NM_214312.3 → NP_999477.2  guanine nucleotide-binding protein G(s) subunit alpha isoform GNASL

    See identical proteins and their annotated locations for NP_999477.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is biallelically expressed and encodes isoform GNASL, also known as alpha-S2, a form of the G-protein alpha subunit.
    Source sequence(s)
    AK238560, AK240484, AK347610, DV937277, EW485651, FS668911, FS710845
    UniProtKB/TrEMBL
    A0A4X1URN3, A0A5G2QYC4, A0A8D0WIW3, A5GFU5, K7GSD2
    Related
    ENSSSCP00000030814.3, ENSSSCT00000035218.4
    Conserved Domains (1) summary
    cd00066
    Location:41 → 388
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RNA

  1. NR_033291.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) has an alternate 5' exon, compared to variant 1. It is paternally expressed and is thought to be a non-coding RNA. It may regulate imprinting of the GNAS transcripts.
    Source sequence(s)
    AK237491, AK238881, EW485651, FS714210

  2. NR_033292.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has an alternate 5' exon and lacks an internal exon, compared to variant 1. It is thought to be a non-coding RNA. It may regulate imprinting of the GNAS transcripts.
    Source sequence(s)
    AK238507, AK238881, EW485651, FS714210

  3. NR_073434.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) has an alternate 5' exon and lacks an internal exon, compared to variant 1. It is thought to be a non-coding RNA. It may regulate imprinting of the GNAS transcripts.
    Source sequence(s)
    AK238560, EW485651, FS714210

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010459.5 Reference Sscrofa11.1 Primary Assembly

    Range
    58985580..59053022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021077156.1 → XP_020932815.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X7

    UniProtKB/TrEMBL
    A0A8D0JKW3
    Related
    ENSSSCP00000029022.2, ENSSSCT00000035506.4
    Conserved Domains (1) summary
    cd00066
    Location:15 → 341
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  2. XM_021077166.1 → XP_020932825.1  SCG6 (secretogranin VI) isoform X10

    UniProtKB/TrEMBL
    A0A4X1URQ7, A0A8D1IPH8, A5GFT7
    Conserved Domains (1) summary
    pfam06390
    Location:1 → 250
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

  3. XM_021077155.1 → XP_020932814.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X6

    UniProtKB/TrEMBL
    A0A8D0JKW3
    Conserved Domains (1) summary
    cd00066
    Location:15 → 342
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  4. XM_021077165.1 → XP_020932824.1  SCG6 (secretogranin VI) isoform X10

    UniProtKB/TrEMBL
    A0A4X1URQ7, A0A8D1IPH8, A5GFT7
    Conserved Domains (1) summary
    pfam06390
    Location:1 → 250
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)

  5. XM_021077154.1 → XP_020932813.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X5

    UniProtKB/TrEMBL
    A0A8D0JKW3
    Conserved Domains (1) summary
    cd00066
    Location:15 → 357
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  6. XM_021077150.1 → XP_020932809.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A4X1UV93, K7GQR9
    Related
    ENSSSCP00000030243.2, ENSSSCT00000033259.4
    Conserved Domains (2) summary
    cd00066
    Location:652 → 1000
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    cl26464
    Location:47 → 358
    Atrophin-1; Atrophin-1 family

  7. XM_021077151.1 → XP_020932810.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A4X1UV93, A0A8D1EFV6, A5GFU0
    Related
    ENSSSCP00000029311.1, ENSSSCT00000033038.4
    Conserved Domains (2) summary
    cd00066
    Location:652 → 999
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    cl26464
    Location:47 → 358
    Atrophin-1; Atrophin-1 family

  8. XM_021077152.1 → XP_020932811.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A4X1UWC8, A0A8W4FAM9
    Related
    ENSSSCP00000076379.1, ENSSSCT00000101976.1
    Conserved Domains (2) summary
    cd00066
    Location:652 → 985
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    cl26464
    Location:47 → 358
    Atrophin-1; Atrophin-1 family

  9. XM_021077153.1 → XP_020932812.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X4

    UniProtKB/TrEMBL
    A0A4X1UWC8, A0A8D1VJL3
    Conserved Domains (2) summary
    cd00066
    Location:652 → 984
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    cl26464
    Location:47 → 358
    Atrophin-1; Atrophin-1 family

  10. XM_021077160.1 → XP_020932819.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X8

    UniProtKB/TrEMBL
    A0A8D0JKW3
    Conserved Domains (1) summary
    cd00066
    Location:1 → 329
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  11. XM_021077163.1 → XP_020932822.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X9

    UniProtKB/TrEMBL
    A0A8D0JKW3
    Conserved Domains (1) summary
    cd00066
    Location:1 → 314
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  12. XM_021077158.1 → XP_020932817.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X8

    UniProtKB/TrEMBL
    A0A8D0JKW3
    Conserved Domains (1) summary
    cd00066
    Location:1 → 329
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  13. XM_021077157.1 → XP_020932816.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X8

    UniProtKB/TrEMBL
    A0A8D0JKW3
    Conserved Domains (1) summary
    cd00066
    Location:1 → 329
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  14. XM_021077162.1 → XP_020932821.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X9

    UniProtKB/TrEMBL
    A0A8D0JKW3
    Conserved Domains (1) summary
    cd00066
    Location:1 → 314
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  15. XM_021077161.1 → XP_020932820.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X9

    UniProtKB/TrEMBL
    A0A8D0JKW3
    Conserved Domains (1) summary
    cd00066
    Location:1 → 314
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

  16. XM_021077164.1 → XP_020932823.1  guanine nucleotide-binding protein G(s) subunit alpha isoform X9

    UniProtKB/TrEMBL
    A0A8D0JKW3
    Conserved Domains (1) summary
    cd00066
    Location:1 → 314
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001128441.1: Suppressed sequence

    Description
    NM_001128441.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29797.1 GenPept UniProtKB/Swiss-Prot:P29797

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