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CFTR cystic fibrosis transmembrane conductance regulator [ Gallus gallus (chicken) ]

Gene ID: 100049619, updated on 13-Apr-2026
Symbol
CFTRprovided by CGNC
Full Name
cystic fibrosis transmembrane conductance regulatorprovided by CGNC
Primary source
CGNC:7086
See related
Ensembl:ENSGALG00010001202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
all
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Try the new Transcripts and proteins table
See CFTR in Genome Data Viewer
Location:
chromosome: 1
Exon count:
28
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (24715298..24799322, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (24975970..25059973, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109156 Neighboring gene cortactin binding protein 2 Neighboring gene uncharacterized LOC121107644 Neighboring gene uncharacterized LOC121107645 Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel. Fay JF, et al. Biochemistry, 2018 Oct 30. PMID 30281975
  2. A role for the cystic fibrosis transmembrane conductance regulator in the nitric oxide-dependent release of Cl(-) from acidic organelles in amacrine cells. Krishnan V, et al. J Neurophysiol, 2017 Nov 1. PMID 28835528, Free PMC Article
  3. CFTR mediated chloride secretion in the avian renal proximal tubule. Laverty G, et al. Comp Biochem Physiol A Mol Integr Physiol, 2012 Jan. PMID 21964154
  4. Comparative analyses of multi-species sequences from targeted genomic regions. Thomas JW, et al. Nature, 2003 Aug 14. PMID 12917688
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. observe an extracellular vestibule that may provide anion access to the pore due to the conformation of transmembrane helices 7 and 8 that differs from the previous orthologue CFTR structures
    Title: Cryo-EM Visualization of an Active High Open Probability CFTR Anion Channel.
  2. Study demonstrated a neuronal role for CFTR in regulating cytosolic Cl- in response to NO, thus regulating the strength or even the sign of postsynaptic GABAergic and glycinergic responses. The involvement of CFTR in this fundamental aspect of neuronal physiology contributes to filling the gap in our understanding of neuronal Cl- regulation.
    Title: A role for the cystic fibrosis transmembrane conductance regulator in the nitric oxide-dependent release of Cl(-) from acidic organelles in amacrine cells.
  3. These data support the conclusion that avian renal proximal tubules utilize an apical CFTR Cl(-) channel to mediate cAMP-activated Cl(-) secretion.
    Title: CFTR mediated chloride secretion in the avian renal proximal tubule.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
cystic fibrosis transmembrane conductance regulator
Names
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
NP_001099136.2
XP_015131458.2
XP_040556204.1
XP_040559742.1
XP_046762185.1
XP_046762186.1
XP_046762187.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105666.2 → NP_001099136.2  cystic fibrosis transmembrane conductance regulator

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/TrEMBL
    A0M8U4, F1P2S7
    Conserved Domains (1) summary
    TIGR01271
    Location:1 → 1471
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    24715298..24799322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040700270.2 → XP_040556204.1  cystic fibrosis transmembrane conductance regulator isoform X2

    UniProtKB/TrEMBL
    A0M8U4, F1P2S7
    Conserved Domains (1) summary
    TIGR01271
    Location:1 → 1443
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)

  2. XM_015275972.4 → XP_015131458.2  cystic fibrosis transmembrane conductance regulator isoform X1

    UniProtKB/TrEMBL
    A0M8U4, F1P2S7
    Related
    ENSGALP00010001330.1, ENSGALT00010002780.1
    Conserved Domains (1) summary
    TIGR01271
    Location:1 → 1472
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)

  3. XM_040703808.2 → XP_040559742.1  cystic fibrosis transmembrane conductance regulator isoform X3

    UniProtKB/TrEMBL
    A0A8V0X9Y9
    Conserved Domains (1) summary
    TIGR01271
    Location:1 → 1390
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    24975970..25059973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906230.1 → XP_046762186.1  cystic fibrosis transmembrane conductance regulator isoform X2

    UniProtKB/TrEMBL
    A0M8U4, F1P2S7

  2. XM_046906229.1 → XP_046762185.1  cystic fibrosis transmembrane conductance regulator isoform X1

    UniProtKB/TrEMBL
    A0M8U4, F1P2S7

  3. XM_046906231.1 → XP_046762187.1  cystic fibrosis transmembrane conductance regulator isoform X3

    UniProtKB/TrEMBL
    A0A8V0X9Y9
Nucleotide Protein
Heading Accession and Version

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