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SIGLEC14 sialic acid binding Ig like lectin 14 [ Homo sapiens (human) ]

Gene ID: 100049587, updated on 25-Jan-2022

Summary

Official Symbol
SIGLEC14provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 14provided by HGNC
Primary source
HGNC:HGNC:32926
See related
Ensembl:ENSG00000254415 MIM:618132; AllianceGenome:HGNC:32926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable sialic acid binding activity. Predicted to be involved in cell adhesion. Predicted to be located in ficolin-1-rich granule membrane and tertiary granule membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in spleen (RPKM 13.9), appendix (RPKM 9.2) and 7 other tissues See more
Orthologs
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Genomic context

See SIGLEC14 in Genome Data Viewer
Location:
19q13.41
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51639478..51646852, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52145814..52150072, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytosolic thiouridylase subunit 1 homolog (S. pombe) pseudogene Neighboring gene sialic acid binding Ig like lectin 5 Neighboring gene ribosomal protein L9 pseudogene 33 Neighboring gene ribosomal protein L7 pseudogene 51 Neighboring gene SPACA6 antisense RNA 1 Neighboring gene sperm acrosome associated 6 Neighboring gene microRNA 99b

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic variants in PLG, LPA and SIGLEC 14 as well as smoking contribute to plasma plasminogen levels.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sialic acid-binding Ig-like lectin 14
Names
siglec-14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098612.3NP_001092082.1  sialic acid-binding Ig-like lectin 14 precursor

    See identical proteins and their annotated locations for NP_001092082.1

    Status: VALIDATED

    Source sequence(s)
    AC018755
    Consensus CDS
    CCDS42604.1
    UniProtKB/Swiss-Prot
    Q08ET2
    Related
    ENSP00000354090.5, ENST00000360844.7
    Conserved Domains (3) summary
    cd05712
    Location:21140
    Ig_Siglec_N; Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
    smart00410
    Location:261336
    IG_like; Immunoglobulin like
    cl11960
    Location:252335
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51639478..51646852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026113.2XP_016881602.1  sialic acid-binding Ig-like lectin 14 isoform X1

RNA

  1. XR_001753563.2 RNA Sequence

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