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edar ectodysplasin A receptor [ Oryzias latipes (Japanese medaka) ]

Gene ID: 100049352, updated on 8-Mar-2024

Summary

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Gene symbol
edar
Gene description
ectodysplasin A receptor
See related
EnsemblRapid:ENSORLG00000015897
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryzias latipes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
Also known as
rs3
Orthologs
human zebrafish all
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Genomic context

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See edar in Genome Data Viewer
Location:
chromosome: 21
Exon count:
13
Annotation release Status Assembly Chr Location
103 current ASM223467v1 (GCF_002234675.1) 21 NC_019879.2 (18020379..18057139, complement)
102 previous assembly ASM31367v1 (GCF_000313675.1) 21 NC_019879.1 (17655885..17694731, complement)

Chromosome 21 - NC_019879.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110017353 Neighboring gene charged multivesicular body protein 2Ba Neighboring gene vestigial-like family member 3 Neighboring gene SH3 domain containing ring finger 3 Neighboring gene septin 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Scale and tooth phenotypes in medaka with a mutated ectodysplasin-A receptor: implications for the evolutionary origin of oral and pharyngeal teeth. Atukorala AD, et al. Arch Histol Cytol, 2010. PMID 22572181
  2. The medaka rs-3 locus required for scale development encodes ectodysplasin-A receptor. Kondo S, et al. Curr Biol, 2001 Aug 7. PMID 11516953
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data suggest differential roles for Eda-Edar signaling in the induction and growth of scales and teeth and support the intrinsic odontogenic competence of the rostral endoderm in medaka.
    Title: Scale and tooth phenotypes in medaka with a mutated ectodysplasin-A receptor: implications for the evolutionary origin of oral and pharyngeal teeth.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member EDAR
Names
RS-3
protein reduced scale-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001104759.1 → NP_001098229.1  tumor necrosis factor receptor superfamily member EDAR precursor

    See identical proteins and their annotated locations for NP_001098229.1

    Status: PROVISIONAL

    Source sequence(s)
    AF364815
    UniProtKB/TrEMBL
    A0A3P9H6N4, A0A3P9LPZ5
    Related
    ENSORLP00000058117.1, ENSORLT00000081192.1
    Conserved Domains (4) summary
    cd00185
    Location:75 → 115
    TNFRSF; CRD2 [structural motif]
    pfam14946
    Location:117 → 208
    DUF4501; Domain of unknown function (DUF4501)
    cl14633
    Location:417 → 473
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl22855
    Location:14 → 149
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: Oryzias latipes Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM223467v1 Primary Assembly

Genomic

  1. NC_019879.2 Reference ASM223467v1 Primary Assembly

    Range
    18020379..18057139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_020712811.2 → XP_020568470.1  tumor necrosis factor receptor superfamily member EDAR isoform X2

    UniProtKB/TrEMBL
    A0A3P9H775
    Related
    ENSORLP00000085748.1, ENSORLT00000061191.1
    Conserved Domains (3) summary
    cd00185
    Location:75 → 115
    TNFRSF; CRD2 [structural motif]
    cl14633
    Location:375 → 431
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl22855
    Location:12 → 149
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  2. XM_023950455.1 → XP_023806223.1  tumor necrosis factor receptor superfamily member EDAR isoform X1

    UniProtKB/Swiss-Prot
    Q90VY2, Q90Z36
    UniProtKB/TrEMBL
    A0A3P9H6N4
    Conserved Domains (4) summary
    cd00185
    Location:75 → 115
    TNFRSF; CRD2 [structural motif]
    pfam14946
    Location:117 → 208
    DUF4501; Domain of unknown function (DUF4501)
    cl14633
    Location:417 → 473
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl22855
    Location:12 → 149
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90VY2.1 GenPept UniProtKB/Swiss-Prot:Q90VY2

Gene LinkOut

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Research Materials