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Tigit T cell immunoreceptor with Ig and ITIM domains [ Mus musculus (house mouse) ]

Gene ID: 100043314, updated on 26-Mar-2023

Summary

Official Symbol
Tigitprovided by MGI
Official Full Name
T cell immunoreceptor with Ig and ITIM domainsprovided by MGI
Primary source
MGI:MGI:3642260
See related
Ensembl:ENSMUSG00000071552 AllianceGenome:MGI:3642260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vstm3
Summary
Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell activation. Predicted to be active in cell surface. Orthologous to human TIGIT (T cell immunoreceptor with Ig and ITIM domains). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 1.9), small intestine adult (RPKM 1.8) and 8 other tissues See more
Orthologs
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Genomic context

See Tigit in Genome Data Viewer
Location:
16; 16 B4
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43469224..43485494, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (43626137..43665125, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 20 Neighboring gene predicted gene 15713 Neighboring gene microRNA 568 Neighboring gene predicted gene, 53956 Neighboring gene dopamine receptor D3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
T-cell immunoreceptor with Ig and ITIM domains
Names
V-set and transmembrane domain containing 3
V-set and transmembrane domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146325.1NP_001139797.1  T-cell immunoreceptor with Ig and ITIM domains precursor

    See identical proteins and their annotated locations for NP_001139797.1

    Status: VALIDATED

    Source sequence(s)
    AC120871, CV307751, EU675311
    Consensus CDS
    CCDS49852.1
    UniProtKB/TrEMBL
    A0A0B4J1G6
    Related
    ENSMUSP00000093770.5, ENSMUST00000096065.6
    Conserved Domains (2) summary
    smart00410
    Location:32127
    IG_like; Immunoglobulin like
    cl11960
    Location:40128
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    43469224..43485494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316834.3XP_017172323.1  T-cell immunoreceptor with Ig and ITIM domains isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:40128
    Ig; Immunoglobulin domain