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Defa37 defensin, alpha, 37 [ Mus musculus (house mouse) ]

Gene ID: 100041895, updated on 8-Dec-2022

Summary

Official Symbol
Defa37provided by MGI
Official Full Name
defensin, alpha, 37provided by MGI
Primary source
MGI:MGI:3705236
See related
Ensembl:ENSMUSG00000065956 AllianceGenome:MGI:3705236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm14850
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; innate immune response in mucosa; and response to bacterium. Predicted to be located in azurophil granule. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA1 (defensin alpha 1); DEFA3 (defensin alpha 3); and DEFA4 (defensin alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward large intestine adult (RPKM 641.3) See more
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Genomic context

See Defa37 in Genome Data Viewer
Location:
8; 8 A2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22055402..22056366)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21565386..21566350)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin, alpha, 32 Neighboring gene predicted gene, 24423 Neighboring gene defensin, alpha, 28 Neighboring gene ribosomal protein L21 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables pore-forming activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alpha-defensin 5-like
Names
novel defensin-related cryptidin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177522.1NP_001170993.1  alpha-defensin 5-like precursor

    See identical proteins and their annotated locations for NP_001170993.1

    Status: VALIDATED

    Source sequence(s)
    AC133094
    Consensus CDS
    CCDS52510.1
    UniProtKB/TrEMBL
    K9J724
    Related
    ENSMUSP00000081053.3, ENSMUST00000084040.3
    Conserved Domains (2) summary
    pfam00323
    Location:6492
    Defensin_1; Mammalian defensin
    pfam00879
    Location:1651
    Defensin_propep; Defensin propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    22055402..22056366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)