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Defa40 defensin, alpha, 40 [ Mus musculus (house mouse) ]

Gene ID: 100041787, updated on 8-Dec-2022

Summary

Official Symbol
Defa40provided by MGI
Official Full Name
defensin, alpha, 40provided by MGI
Primary source
MGI:MGI:3708769
See related
Ensembl:ENSMUSG00000074441 AllianceGenome:MGI:3708769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm15292
Summary
Predicted to enable protein homodimerization activity. Predicted to be involved in several processes, including cellular response to lipopolysaccharide; defense response to other organism; and positive regulation of membrane permeability. Predicted to be located in intracellular membrane-bounded organelle and midbody. Predicted to be active in extracellular space. Orthologous to several human genes including DEFA3 (defensin alpha 3) and DEFA6 (defensin alpha 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward large intestine adult (RPKM 47.8) See more
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Genomic context

See Defa40 in Genome Data Viewer
Location:
8 A2; 8
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (21739731..21740569)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21249715..21250553)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defensin, alpha, pseudogene 6 Neighboring gene zinc finger, MYM-type 5 pseudogene Neighboring gene defensin, alpha, pseudogene 8 Neighboring gene defensin, alpha, 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables pore-forming activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
uncharacterized protein LOC100041787
Names
novel defensin-related cryptidin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177487.2NP_001170958.1  uncharacterized protein LOC100041787 precursor

    Status: VALIDATED

    Source sequence(s)
    AC129174
    Consensus CDS
    CCDS52507.1
    UniProtKB/TrEMBL
    L7N231
    Related
    ENSMUSP00000096494.3, ENSMUST00000098895.3
    Conserved Domains (2) summary
    pfam00323
    Location:6492
    Defensin_1; Mammalian defensin
    pfam00879
    Location:1651
    Defensin_propep; Defensin propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    21739731..21740569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)