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Fancf Fanconi anemia, complementation group F [ Mus musculus (house mouse) ]

Gene ID: 100040608, updated on 9-May-2024

Summary

Official Symbol
Fancfprovided by MGI
Official Full Name
Fanconi anemia, complementation group Fprovided by MGI
Primary source
MGI:MGI:3689889
See related
Ensembl:ENSMUSG00000092118 AllianceGenome:MGI:3689889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730016A17
Summary
Contributes to ubiquitin protein ligase activity. Acts upstream of or within several processes, including ovarian follicle development; protein ubiquitination; and spermatogenesis. Part of Fanconi anaemia nuclear complex. Used to study primary ovarian insufficiency. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group F; adenocarcinoma in situ; and granulosa cell tumor. Orthologous to human FANCF (FA complementation group F). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Fancf in Genome Data Viewer
Location:
7 B4; 7 32.87 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (51510325..51512015, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (51860577..51862267, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene VISTA enhancer mm683 Neighboring gene predicted gene, 33290 Neighboring gene growth arrest specific 2 Neighboring gene STARR-seq mESC enhancer starr_18929 Neighboring gene STARR-seq mESC enhancer starr_18930 Neighboring gene STARR-positive B cell enhancer mm9_chr7:59261106-59261406 Neighboring gene small VCP/p97-interacting protein Neighboring gene coiled-coil domain containing 179

Genomic regions, transcripts, and products

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
involved_in interstrand cross-link repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Fanconi anaemia nuclear complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Fanconi anaemia nuclear complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of Fanconi anaemia nuclear complex ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Fanconi anemia group F protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001115087.1NP_001108559.1  Fanconi anemia group F protein

    Status: VALIDATED

    Source sequence(s)
    AC158345
    Consensus CDS
    CCDS52261.1
    UniProtKB/Swiss-Prot
    E9Q5Z5
    Related
    ENSMUSP00000125812.2, ENSMUST00000169357.2
    Conserved Domains (1) summary
    pfam11107
    Location:1333
    FANCF; Fanconi anemia group F protein (FANCF)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    51510325..51512015 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)