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Pira12 paired-Ig-like receptor A12 [ Mus musculus (house mouse) ]

Gene ID: 100038909, updated on 8-Dec-2022

Summary

Official Symbol
Pira12provided by MGI
Official Full Name
paired-Ig-like receptor A12provided by MGI
Primary source
MGI:MGI:3709645
See related
Ensembl:ENSMUSG00000074417 AllianceGenome:MGI:3709645
Gene type
protein coding
RefSeq status
INFERRED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm14548
Summary
Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to be active in plasma membrane. Orthologous to human LILRB5 (leukocyte immunoglobulin like receptor B5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 29.6), mammary gland adult (RPKM 15.0) and 13 other tissues See more
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Genomic context

See Pira12 in Genome Data Viewer
Location:
7; 7 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3887200..3901158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3884201..3898159, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene paired-Ig-like receptor A2 Neighboring gene predicted pseudogene 10693 Neighboring gene leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 Neighboring gene RIKEN cDNA 1700095K22 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgM binding ISO
Inferred from Sequence Orthology
more info
 
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Fc-epsilon receptor I complex ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
paired-Ig-like receptor A12; predicted gene 14548

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166672.2NP_001160144.1  paired-Ig-like receptor A12 precursor 1 precursor

    Status: INFERRED

    Source sequence(s)
    AC161409
    UniProtKB/TrEMBL
    E9Q1Z6
    Related
    ENSMUSP00000070073.8, ENSMUST00000070639.8
    Conserved Domains (2) summary
    smart00410
    Location:529617
    IG_like; Immunoglobulin like
    cl11960
    Location:225315
    Ig; Immunoglobulin domain
  2. NM_001384210.1NP_001371139.1  paired-Ig-like receptor A12 precursor 2 precursor

    Status: INFERRED

    Source sequence(s)
    AC161409
    Conserved Domains (3) summary
    cd00096
    Location:124128
    Ig; Ig strand A [structural motif]
    cd16843
    Location:225314
    IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:123219
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3887200..3901158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539428.4XP_006539491.1  predicted gene 14548 isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:225315
    Ig; Immunoglobulin domain
  2. XM_006539430.2XP_006539493.1  predicted gene 14548 isoform X3

    Conserved Domains (1) summary
    cl11960
    Location:27118
    Ig; Immunoglobulin domain
  3. XM_006539429.5XP_006539492.1  predicted gene 14548 isoform X2

    Conserved Domains (1) summary
    cl11960
    Location:225315
    Ig; Immunoglobulin domain