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Isg15 ISG15 ubiquitin-like modifier [ Mus musculus (house mouse) ]

Gene ID: 100038882, updated on 26-Jun-2024

Summary

Official Symbol
Isg15provided by MGI
Official Full Name
ISG15 ubiquitin-like modifierprovided by MGI
Primary source
MGI:MGI:1855694
See related
Ensembl:ENSMUSG00000035692 AllianceGenome:MGI:1855694
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G1p2; IP17; Irfp; UCRP; IGI15
Summary
Enables protein tag. Involved in several processes, including ISG15-protein conjugation; defense response to other organism; and positive regulation of erythrocyte differentiation. Acts upstream of or within modification-dependent protein catabolic process and response to bacterium. Predicted to be located in extracellular region. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 38. Orthologous to human ISG15 (ISG15 ubiquitin like modifier). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 20.5), placenta adult (RPKM 4.4) and 11 other tissues See more
Orthologs
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Genomic context

See Isg15 in Genome Data Viewer
Location:
4 E2; 4 88.61 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156283881..156285275, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156199424..156200818, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ring finger 223 Neighboring gene STARR-seq mESC enhancer starr_12288 Neighboring gene STARR-seq mESC enhancer starr_12289 Neighboring gene agrin Neighboring gene STARR-seq mESC enhancer starr_12290 Neighboring gene STARR-seq mESC enhancer starr_12291 Neighboring gene predicted gene, 46878 Neighboring gene STARR-positive B cell enhancer ABC_E2735 Neighboring gene expressed sequence AW011738 Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1 Neighboring gene predicted gene, 46877

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC18616, MGC103144, MGC130321

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tag activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tag activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in ISG15-protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ISG15-protein conjugation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ISG15-protein conjugation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ISG15-protein conjugation ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within modification-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein oligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to type I interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin-like protein ISG15
Names
interferon, alpha-inducible protein
interferon-induced 15 kDa protein
interferon-induced 15-KDa protein
interferon-induced 17 kDa protein
interferon-stimulated protein (15 kDa)
interferon-stimulated protein 15
ubiquitin cross-reactive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015783.3NP_056598.2  ubiquitin-like protein ISG15

    See identical proteins and their annotated locations for NP_056598.2

    Status: VALIDATED

    Source sequence(s)
    CT998563
    Consensus CDS
    CCDS51405.1
    UniProtKB/Swiss-Prot
    Q64339, Q8K0H3
    UniProtKB/TrEMBL
    Q4FJR9
    Related
    ENSMUSP00000082548.5, ENSMUST00000085425.6
    Conserved Domains (2) summary
    cd01792
    Location:375
    Ubl1_ISG15; ubiquitin-like (Ubl) domain 1 found in interferon-stimulated gene 15 (ISG15) and similar proteins
    cd01810
    Location:80153
    Ubl2_ISG15; ubiquitin-like (Ubl) domain 2 found in interferon-stimulated gene 15 (ISG15) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    156283881..156285275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)