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tnfrsf1b tumor necrosis factor receptor superfamily, member 1B [ Danio rerio (zebrafish) ]

Gene ID: 100037357, updated on 8-Mar-2025

Summary

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Official Symbol
tnfrsf1bprovided by ZNC
Official Full Name
tumor necrosis factor receptor superfamily, member 1Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070410-133
See related
Ensembl:ENSDARG00000070165 AllianceGenome:ZFIN:ZDB-GENE-070410-133
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rank; tnfr2; zgc:163064
Summary
Predicted to enable signaling receptor activity. Involved in positive regulation of hematopoietic stem cell differentiation. Acts upstream of or within several processes, including peripheral nervous system axon ensheathment; positive regulation of hematopoietic progenitor cell differentiation; and regulation of non-canonical NF-kappaB signal transduction. Is active in plasma membrane. Is expressed in several structures, including head; head mesenchyme; hematopoietic system; osteoclast; and scale. Used to study psoriasis. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Orthologous to several human genes including TNFRSF1B (TNF receptor superfamily member 1B). [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
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Genomic context

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See tnfrsf1b in Genome Data Viewer
Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (40430247..40457162, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (40166644..40193006, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:dkey-207b20.2 Neighboring gene tripartite motif containing 62, tandem duplicate 1 Neighboring gene si:dkeyp-61b2.1 Neighboring gene migration and invasion inhibitory protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification and functional characterization of grass carp (Ctenopharyngodon idella) tumor necrosis factor receptor 2 and its soluble form with potentiality for targeting inflammation. Zhang S, et al. Fish Shellfish Immunol, 2019 Mar. PMID 30502465
  2. Liquiritigenin Reduces Blood Glucose Level and Bone Adverse Effects in Hyperglycemic Adult Zebrafish. Carnovali M, et al. Nutrients, 2019 May 9. PMID 31075971, Free PMC Article
  3. Osteoclast-like Cells in Early Zebrafish Embryos. Sharif F, et al. Cell J, 2014 Summer. PMID 24567948, Free PMC Article
  4. Chronic hyperglycemia affects bone metabolism in adult zebrafish scale model. Carnovali M, et al. Endocrine, 2016 Dec. PMID 27696252
  5. Metabolic and bone effects of high-fat diet in adult zebrafish. Carnovali M, et al. Endocrine, 2018 Aug. PMID 29274064

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Targeted gene knockdown of TNFRSF1B in zebrafish embryos results in the induction of a caspase-8, caspase-2 and P53-dependent apoptotic program in endothelial cells that bypasses caspase-3.
    Title: TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within peripheral nervous system axon ensheathment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of hematopoietic progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089510.2 → NP_001082979.2  tumor necrosis factor receptor superfamily member 1B precursor

    Status: VALIDATED

    Source sequence(s)
    CR848022, CR926132
    UniProtKB/TrEMBL
    A0A8M2B220, F1RAS9
    Related
    ENSDARP00000104953.2, ENSDART00000128442.4
    Conserved Domains (3) summary
    cd00185
    Location:163 → 200
    TNFRSF; CRD2 [structural motif]
    cd15835
    Location:31 → 160
    TNFRSF1B_teleost; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) in teleost; also known as TNFR2
    cl22855
    Location:141 → 200
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    40430247..40457162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155914.5 → XP_005155971.1  tumor necrosis factor receptor superfamily member 1B isoform X1

    UniProtKB/TrEMBL
    A0A8M2B2L3
    Conserved Domains (3) summary
    cd00185
    Location:163 → 200
    TNFRSF; CRD2 [structural motif]
    cd15835
    Location:31 → 160
    TNFRSF1B_teleost; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) in teleost; also known as TNFR2
    cl22855
    Location:141 → 200
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein Strain
Heading Accession and Version

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