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TNFRSF1B TNF receptor superfamily member 1B [ Sus scrofa (pig) ]

Gene ID: 100037306, updated on 1-Mar-2025

Summary

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Official Symbol
TNFRSF1Bprovided by VGNC
Official Full Name
TNF receptor superfamily member 1Bprovided by VGNC
Primary source
VGNC:VGNC:94264
See related
Ensembl:ENSSSCG00000022208 RGD:14028357
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
TNFR2
Expression
Broad expression in lung (RPKM 80.8), spleen (RPKM 53.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See TNFRSF1B in Genome Data Viewer
Location:
chromosome: 6
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (72195420..72231146)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) Unplaced Scaffold NW_003541150.1 (15875..31914, complement)

Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene migration and invasion inhibitory protein Neighboring gene TNF receptor superfamily member 8 Neighboring gene vacuolar protein sorting 13 homolog D Neighboring gene dehydrogenase/reductase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Identification of soluble and membrane-bound isoforms of porcine tumor necrosis factor receptor 2. Uribe-Herranz M, et al. Xenotransplantation, 2011 Mar-Apr. PMID 21496120
  2. Characterization of porcine tumor necrosis factor receptor 2: implications for xenotransplantation. Costa C, et al. Transplant Proc, 2007 Sep. PMID 17889214
  3. Molecular cloning of porcine (Sus scrofa) tumor necrosis factor receptor 2. Cheng Y, et al. J Reprod Dev, 2007 Dec. PMID 17827878
  4. Tumor necrosis factor and its receptors in the neuroretina and retinal vasculature after ischemia-reperfusion injury in the pig retina. Gesslein B, et al. Mol Vis, 2010 Nov 6. PMID 21152396, Free PMC Article
  5. Stent implantation in coronary porcine arteries is associated with early activation of TNFalpha and TNFalpha receptor II expression. Hadjadj S, et al. Atherosclerosis, 2007 May. PMID 16857205

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Retinal ischemia results in increased expression of TNF-alpha and its receptors (TNF-R1 and TNF-R2).
    Title: Tumor necrosis factor and its receptors in the neuroretina and retinal vasculature after ischemia-reperfusion injury in the pig retina.
  2. Porcine TNFR2 (1,125 bp, 375 amino acid residues), which contains specific amino acid region of transmembrane, indicated high identities with human and murine TNFR2
    Title: Molecular cloning of porcine (Sus scrofa) tumor necrosis factor receptor 2.
  3. pTNFR2 isoforms may play differential roles in the process of xenograft rejection.
    Title: Characterization of porcine tumor necrosis factor receptor 2: implications for xenotransplantation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables tumor necrosis factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of neuroinflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of myelination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of T cell cytokine production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 1B
Names
tumor necrosis factor receptor 2
tumor necrosis factor receptor superfamily, member 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097441.2 → NP_001090910.2  tumor necrosis factor receptor superfamily member 1B precursor

    See identical proteins and their annotated locations for NP_001090910.2

    Status: PROVISIONAL

    Source sequence(s)
    EU116354
    UniProtKB/TrEMBL
    A7Y2G6, F4ZMP8
    Related
    ENSSSCP00000025907.2, ENSSSCT00000028399.3
    Conserved Domains (1) summary
    cd10577
    Location:40 → 203
    TNFRSF1B; Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B), also known as TNFR2

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

    Range
    72195420..72231146
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021093133.1 → XP_020948792.1  tumor necrosis factor receptor superfamily member 1B isoform X1

    UniProtKB/TrEMBL
    A0A4X1W9C3, A0A8D1WPE9, F4ZMP9, I3LKD0
    Related
    ENSSSCP00000024544.2, ENSSSCT00000022767.4
    Conserved Domains (1) summary
    cl22855
    Location:40 → 153
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein
Heading Accession and Version

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