Niban3 niban apoptosis regulator 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Niban3provided by MGI
Official Full Name: niban apoptosis regulator 3provided by MGI
Primary source: MGI:MGI:3686743
See related: Ensembl:ENSMUSG00000043243 AllianceGenome:MGI:3686743
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bcnp1; Fam129c
Summary: Orthologous to human NIBAN3 (niban apoptosis regulator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 24.5), thymus adult (RPKM 3.3) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 B3.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (72049000..72061599)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (71596356..71608146)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The BCNP1-deficient spleen B cells show enhanced survival, proliferation and Ca2+ influx in response to BCR cross-linking as compared with wild-type spleen B cells.
Title: Distinct roles of BCNP1 in B-cell development and activation.
These results demonstrate that BCNP1 promotes B-cell receptor signaling
Title: The B cell novel protein 1 (BCNP1) regulates BCR signaling and B cell apoptosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

AI447866 (e-PCR)
- UniSTS:159774

39.MMHAP64FLE6.seq (e-PCR)
- UniSTS:159775

Homology

Homologs of the Niban3 gene: The Niban3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 227 organisms have orthologs with human gene Niban3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: protein Niban 3

Names: BCNP1 homolog; family with sequence similarity 129, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166213.2 → NP_001159685.1 protein Niban 3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC162033

Consensus CDS

CCDS52587.1

UniProtKB/TrEMBL

D3YZB0

Related

ENSMUSP00000123432.2, ENSMUST00000143662.8
NM_001384129.1 → NP_001371058.1 protein Niban 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform.

Source sequence(s)

AC162033