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Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 [ Mus musculus (house mouse) ]

Gene ID: 100037258, updated on 2-Jul-2024

Summary

Official Symbol
Dnajc3provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C3provided by MGI
Primary source
MGI:MGI:107373
See related
Ensembl:ENSMUSG00000022136 AllianceGenome:MGI:107373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p58; mp58; Prkri; p58IPK; Dnajc3a; Dnajc3b
Summary
Enables several functions, including chaperone binding activity; misfolded protein binding activity; and protein kinase inhibitor activity. Involved in cellular response to cold; proteolysis involved in cellular protein catabolic process; and regulation of translational initiation. Located in cytosol and endoplasmic reticulum lumen. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human DNAJC3 (DnaJ heat shock protein family (Hsp40) member C3). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: On Build36, NCBI annotated NC_000080.4:117820545..117862457 as Dnajc3 with MGI:107373. Mouse Genome Informatics (MGI) defined that location as Dnajc3b, MGI:3696572. On April 10, 2006, NCBI renamed that location to conform to the definition by MGI. With Build37, the duplicate annotation was no longer required, because the component CT025524.8 was removed from the assembly. [13 Feb 2013]
Expression
Ubiquitous expression in placenta adult (RPKM 26.5), genital fat pad adult (RPKM 18.7) and 28 other tissues See more
Orthologs
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Genomic context

See Dnajc3 in Genome Data Viewer
Location:
14 E4; 14 62.6 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (119175371..119219114)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118937932..118981702)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:119237797-119237998 Neighboring gene claudin 10 Neighboring gene predicted gene, 32382 Neighboring gene STARR-positive B cell enhancer ABC_E4125 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:119381910-119382076 Neighboring gene DAZ interacting protein 1 Neighboring gene STARR-positive B cell enhancer mm9_chr14:119406665-119406966 Neighboring gene coiled-coil domain-containing protein 58 pseudogene Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2 Neighboring gene predicted gene, 16835 Neighboring gene STARR-seq mESC enhancer starr_37667 Neighboring gene STARR-seq mESC enhancer starr_37668 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene STARR-seq mESC enhancer starr_37669 Neighboring gene tera pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC6474

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables misfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily C member 3
Names
DnaJ (Hsp40) homolog, subfamily C, member 3
DnaJ (Hsp40) homolog, subfamily C, member 3A
DnaJ (Hsp40) homolog, subfamily C, member 3B
interferon-induced, double-stranded RNA-activated protein kinase inhibitor
protein kinase inhibitor of 58 kDa
protein kinase inhibitor p58
protein kinase, interferon inducible double stranded RNA dependent inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008929.4NP_032955.2  dnaJ homolog subfamily C member 3 precursor

    See identical proteins and their annotated locations for NP_032955.2

    Status: VALIDATED

    Source sequence(s)
    AC154377
    Consensus CDS
    CCDS37012.1
    UniProtKB/Swiss-Prot
    Q60873, Q91YW3
    UniProtKB/TrEMBL
    Q3UFV9, Q3UKA1
    Related
    ENSMUSP00000022734.8, ENSMUST00000022734.9
    Conserved Domains (6) summary
    COG0484
    Location:392498
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:3765
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:394459
    DnaJ; DnaJ domain
    pfam00515
    Location:107137
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:36100
    TPR_11; TPR repeat
    pfam14559
    Location:318382
    TPR_19; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    119175371..119219114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)