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Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 [ Mus musculus (house mouse) ]

Gene ID: 100037258, updated on 31-Jan-2019

Summary

Official Symbol
Dnajc3provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C3provided by MGI
Primary source
MGI:MGI:107373
See related
Ensembl:ENSMUSG00000022136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p58; mp58; Prkri; p58IPK; Dnajc3a; Dnajc3b; AA408985; AU067833
Annotation information
Note: On Build36, NCBI annotated NC_000080.4:117820545..117862457 as Dnajc3 with MGI:107373. Mouse Genome Informatics (MGI) defined that location as Dnajc3b, MGI:3696572. On April 10, 2006, NCBI renamed that location to conform to the definition by MGI. With Build37, the duplicate annotation was no longer required, because the component CT025524.8 was removed from the assembly. [13 Feb 2013]
Expression
Ubiquitous expression in placenta adult (RPKM 26.5), genital fat pad adult (RPKM 18.7) and 28 other tissues See more
Orthologs

Genomic context

See Dnajc3 in Genome Data Viewer
Location:
14; 14 E4
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (118937932..118981702)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (119337154..119380924)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene claudin 10 Neighboring gene predicted gene, 32382 Neighboring gene coiled-coil domain-containing protein 58 pseudogene Neighboring gene DAZ interacting protein 1 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2 Neighboring gene predicted gene, 16835 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene tera pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from BioSystems

  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC6474

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily C member 3
Names
DnaJ (Hsp40) homolog, subfamily C, member 3
DnaJ (Hsp40) homolog, subfamily C, member 3A
DnaJ (Hsp40) homolog, subfamily C, member 3B
interferon-induced, double-stranded RNA-activated protein kinase inhibitor
protein kinase inhibitor of 58 kDa
protein kinase inhibitor p58
protein kinase, interferon inducible double stranded RNA dependent inhibitor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008929.3NP_032955.2  dnaJ homolog subfamily C member 3 precursor

    See identical proteins and their annotated locations for NP_032955.2

    Status: VALIDATED

    Source sequence(s)
    AC154377, AK148270, BB618718, BE685675
    Consensus CDS
    CCDS37012.1
    UniProtKB/Swiss-Prot
    Q91YW3
    UniProtKB/TrEMBL
    Q3UFV9
    Related
    ENSMUSP00000022734.7, ENSMUST00000022734.8
    Conserved Domains (6) summary
    COG0484
    Location:392498
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:3765
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:394459
    DnaJ; DnaJ domain
    pfam00515
    Location:107137
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:36100
    TPR_11; TPR repeat
    pfam14559
    Location:318382
    TPR_19; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    118937932..118981702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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