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pak4 p21 protein (Cdc42/Rac)-activated kinase 4 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100036644, updated on 20-Jun-2018

Summary

Symbol
pak4provided by Xenbase
Full Name
p21 protein (Cdc42/Rac)-activated kinase 4provided by Xenbase
Primary source
Xenbase:XB-GENE-1013749
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
pak-4
Orthologs

Genomic context

See pak4 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
103 current Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (59703511..59737468)
102 previous assembly Xtropicalis_v7 (GCF_000004195.2) Unplaced Scaffold NW_004668241.1 (54734239..54767671)

Chromosome 8 - NC_030684.1Genomic Context describing neighboring genes Neighboring gene F-box protein 27 Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene acid phosphatase 7, tartrate resistant (putative) Neighboring gene non-specific cytotoxic cell receptor protein 1 homolog Neighboring gene syncollin

Genomic regions, transcripts, and products

Pathways from BioSystems

  • ErbB signaling pathway, organism-specific biosystem (from KEGG)
    ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • ErbB signaling pathway, conserved biosystem (from KEGG)
    ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton

General gene information

Homology

General protein information

Preferred Names
serine/threonine-protein kinase PAK 4
Names
p21-activated kinase 4
NP_001090671.1
XP_012823244.1
XP_012823245.1
XP_017951568.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097202.1NP_001090671.1  serine/threonine-protein kinase PAK 4

    See identical proteins and their annotated locations for NP_001090671.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127316
    UniProtKB/TrEMBL
    A0JP99
    Conserved Domains (2) summary
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:359650
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_tropicalis_v9.1 Primary Assembly

Genomic

  1. NC_030684.1 Reference Xenopus_tropicalis_v9.1 Primary Assembly

    Range
    59703511..59737468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018096079.1XP_017951568.1  serine/threonine-protein kinase PAK 4 isoform X2

  2. XM_012967791.2XP_012823245.1  serine/threonine-protein kinase PAK 4 isoform X3

    See identical proteins and their annotated locations for XP_012823245.1

    UniProtKB/TrEMBL
    A0JP99
    Conserved Domains (2) summary
    cd01093
    Location:955
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:359650
    PKc_like; Protein Kinases, catalytic domain
  3. XM_012967790.2XP_012823244.1  serine/threonine-protein kinase PAK 4 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:400646
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:2470
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:374665
    PKc_like; Protein Kinases, catalytic domain
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