LOC100034242 alcohol dehydrogenase-E-isoenzyme [Equus caballus (horse)] - Gene

Summary

Gene symbol: LOC100034242
Gene description: alcohol dehydrogenase-E-isoenzyme
See related: Ensembl:ENSECAG00000034047
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as: ADH1E
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Genomic context

Location:: chromosome: 3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	TB-T2T (GCF_041296265.1)	3	NC_091686.1 (45653215..45668707)
RS_2024_08	previous assembly	EquCab3.0 (GCF_002863925.1)	3	NC_009146.3 (40667230..40682661)

Chromosome 3 - NC_091686.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Thoroughbred Stallion gene expression
BioProject: PRJEB53382
Analysis date: Mon Jan 06 09:53:19 2025

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The S48T/F93A substitutions of ADH1E (alcohol dehydrogenase 1E) invert the enantioselectivity for alcohol oxidation, increasing the R/S ratio by 10, 590, and 200-fold for 2-butanol, 2-octanol, and sec-phenethyl alcohol.
Title: Inversion of substrate stereoselectivity of horse liver alcohol dehydrogenase by substitutions of Ser-48 and Phe-93.
In liver alcohol dehydrogenase with NAD(+) the nicotinamide ring is strained toward the transition state on the path to alcohol oxidation.
Title: Atomic-resolution structures of horse liver alcohol dehydrogenase with NAD(+) and fluoroalcohols define strained Michaelis complexes.
The enzyme-NADH complex has a closed conformation similar to that of ternary complexes with coenzyme and substrate analogues; the coordination of the catalytic zinc is similar to that found in the apoenzyme, except that a minor, alternative position for the catalytic zinc is approximately 1.3 A from the major position and closer to Glu-68, which could form the alternative coordination to the catalytic zinc.
Title: Horse Liver Alcohol Dehydrogenase: Zinc Coordination and Catalysis.

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General gene information

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Markers

RH94448 (e-PCR)
- UniSTS:119696

ADH1B (e-PCR)
- UniSTS:503452

ADH1A (e-PCR)
- UniSTS:503453

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in retinoic acid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: alcohol dehydrogenase E chain

Names: Alcohol dehydrogenase S chain; alcohol dehydrogenase-S-isoenzyme

NP_001075997.1

EC 1.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.