EDNRB endothelin receptor type B [Equus caballus (horse)] - Gene

Summary

Official Symbol: EDNRBprovided by VGNC
Official Full Name: endothelin receptor type Bprovided by VGNC
Primary source: VGNC:VGNC:17425
See related: Ensembl:ENSECAG00000024851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_12	current	TB-T2T (GCF_041296265.1)	17	NC_091700.1 (71053794..71075557, complement)
RS_2024_08	previous assembly	EquCab3.0 (GCF_002863925.1)	17	NC_009160.3 (50482550..50504313, complement)

Chromosome 17 - NC_091700.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Thoroughbred Stallion gene expression
BioProject: PRJEB53382
Analysis date: Mon Jan 06 09:53:19 2025

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR antagonists might be beneficial for treatment of laminitis in horses.
Title: Effect of short-term hyperinsulinemia on the localization and expression of endothelin receptors A and B in lamellar tissue of the forelimbs of horses.
both ETA and ETB receptors are involved in the net tonic response to ET-1 in normal laminar veins; a population of ETB receptors may be present on the vascular endothelium and on smooth muscle of laminar veins
Title: Endothelin mediated contraction of equine laminar veins.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables endothelin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in developmental pigmentation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in endothelin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in enteric nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: endothelin receptor type B

Names: ET-B; ET-BR; endothelin B receptor; endothelin receptor non-selective type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.