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TNKS2 tankyrase 2 [ Monodelphis domestica (gray short-tailed opossum) ]

Gene ID: 100024392, updated on 18-Sep-2024

Summary

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Gene symbol
TNKS2
Gene description
tankyrase 2
See related
EnsemblRapid:ENSMODG00000006738
Gene type
protein coding
RefSeq status
MODEL
Organism
Monodelphis domestica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis
Orthologs
human mouse all
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Genomic context

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See TNKS2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2023_05 current mMonDom1.pri (GCF_027887165.1) 1 NC_077227.1 (83906695..83968141, complement)
103 previous assembly MonDom5 (GCF_000002295.2) 1 NC_008801.1 (79429662..79490946, complement)

Chromosome 1 - NC_077227.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene uncharacterized LOC107650576 Neighboring gene protein phosphatase 1 regulatory subunit 3C Neighboring gene 60S ribosomal protein L12-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization to ciliary inversin compartment IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary inversin compartment IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
poly [ADP-ribose] polymerase tankyrase-2
Names
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_027887165.1-RS_2023_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mMonDom1.pri

Genomic

  1. NC_077227.1 Reference mMonDom1.pri

    Range
    83906695..83968141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001375634.5 → XP_001375671.1  poly [ADP-ribose] polymerase tankyrase-2

    UniProtKB/TrEMBL
    A0A5F8GFD9, F7CDC2
    Related
    ENSMODP00000008352.2, ENSMODT00000008519.5
    Conserved Domains (7) summary
    cd09524
    Location:874 → 939
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    smart00454
    Location:880 → 936
    SAM; Sterile alpha motif
    cd00204
    Location:520 → 645
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01438
    Location:941 → 1163
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    pfam00644
    Location:955 → 1158
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    pfam12796
    Location:532 → 624
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:530 → 558
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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