HPX hemopexin [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: HPX
Gene description: hemopexin
See related: Ensembl:ENSOCUG00000016940
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_11	current	mOryCun1.1 (GCF_964237555.1)	1	NC_091432.1 (60444058..60452535)
RS_2023_02	previous assembly	UM_NZW_1.0 (GCF_009806435.1)	1	NC_067374.1 (161300728..161309202, complement)

Chromosome 1 - NC_091432.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that apo-hemopexin isolated from plasma exchibits low endogenous levels of tyrosine nitration in the peptide YYCFQGNQFLR in the heme-binding site of human hemopexin, which was similarly nitrated in rabbit and rat hemopexins; heme binding by hemopexin declined as tyrosine nitration proceeded in vitro.
Title: Identification of oxidative modifications of hemopexin and their predicted physiological relevance.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heme transmembrane transporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in heme transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: hemopexin

NP_001076229.1

EC 3.2.1.35

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082760.1 → NP_001076229.1 hemopexin precursor

See identical proteins and their annotated locations for NP_001076229.1

Status: PROVISIONAL

Source sequence(s)

X16429

UniProtKB/Swiss-Prot

P20058

UniProtKB/TrEMBL

G1TVS4

Related

ENSOCUP00000021163.2, ENSOCUT00000024253.2

Conserved Domains (1) summary

cd00094
Location:54 → 233

HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...