ACTA1 actin alpha 1, skeletal muscle [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: ACTA1
Gene description: actin alpha 1, skeletal muscle
See related: Ensembl:ENSOCUG00000007566
Gene type: protein coding
RefSeq status: MODEL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as: ACTA
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	Unplaced Scaffold	NW_026259269.1 (95885..98853)

NW_026259269.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NW_026259269 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A functional family of fluorescent nucleotide analogues to investigate actin dynamics and energetics.
Title: A functional family of fluorescent nucleotide analogues to investigate actin dynamics and energetics.
Data show that local actin monomer depletion and network architecture can tune the rate of network growth to impose steering during motility.
Title: Network heterogeneity regulates steering in actin-based motility.
Data suggest that mutations in troponin C (TnC) found in patients with hypertrophic cardiomyopathy (A8V, C84Y, and D145E) stabilize the active state of regulated actin (the actin-tropomyosin-troponin complex) to various extents; at a saturating Ca2+ concentration, all TnC mutants investigated increase the level of active M state compared to the wild type.
Title: Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT.
altered TM-actin contacts destabilized the thin filament and affected the actin-myosin interactions
Title: Abnormal movement of tropomyosin and response of myosin heads and actin during the ATPase cycle caused by the Arg167His, Arg167Gly and Lys168Glu mutations in TPM1 gene.
Structure of a Bud6/Actin complex reveals a novel wh2-like actin monomer recruitment motif.
Title: Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.
Data suggest that toxofilin has two actin binding sites, and and the affinities of these actin binding sites are identical or very close to each other.
Title: The effect of toxofilin on the structure and dynamics of monomeric actin.
The activation of vinculin by stretched talin induces a positive feedback that reinforces the actin-talin-vinculin association.
Title: Actomyosin-dependent formation of the mechanosensitive talin-vinculin complex reinforces actin anchoring.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC156330P1 (e-PCR)
- UniSTS:271392

PMC23952P1 (e-PCR)
- UniSTS:272216

PMC109445P1 (e-PCR)
- UniSTS:270169

PMC110143P1 (e-PCR)
- UniSTS:270184

Acta1 (e-PCR), detects polymorphism
- UniSTS:478947

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in skeletal muscle thin filament assembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in actin filament	IEA Inferred from Electronic Annotation more info	PubMed
located_in stress fiber	IEA Inferred from Electronic Annotation more info	PubMed
located_in striated muscle thin filament	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: actin, alpha skeletal muscle

Names: Actin, alpha skeletal muscle; Alpha-actin-1; cytoplasmic beta-actin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

NW_026259269.1 Reference UM_NZW_1.0 Primary Assembly

Range

95885..98853

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_051838163.1 → XP_051694123.1 actin, alpha skeletal muscle

UniProtKB/Swiss-Prot

P68135

UniProtKB/TrEMBL

G1SL06
XM_002722894.4 → XP_002722940.2 actin, alpha skeletal muscle

UniProtKB/Swiss-Prot

P68135

UniProtKB/TrEMBL

G1SL06