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SHMT1 serine hydroxymethyltransferase 1 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009405, updated on 8-Apr-2026
Gene symbol
SHMT1
Gene description
serine hydroxymethyltransferase 1
See related
Ensembl:ENSOCUG00000021541
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
MEL-32
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Try the new Transcripts and proteins table
See SHMT1 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 17 NC_091448.1 (62193284..62217249)

Chromosome 17 - NC_091448.1Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase associated protein 2 Neighboring gene uncharacterized LOC138846264 Neighboring gene SMCR8-C9orf72 complex subunit Neighboring gene DNA topoisomerase III alpha Neighboring gene mitochondrial elongation factor 2

Genomic Sequence:
NC_091448.1 Chromosome 17 Reference mOryCun1.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure-based mechanism for early PLP-mediated steps of rabbit cytosolic serine hydroxymethyltransferase reaction. Di Salvo ML, et al. Biomed Res Int, 2013. PMID 23956983, Free PMC Article
  2. Crystal structure of rabbit cytosolic serine hydroxymethyltransferase at 2.8 A resolution: mechanistic implications. Scarsdale JN, et al. Biochemistry, 1999 Jun 29. PMID 10387080
  3. Evidence for a sulfhydryl group at the active site of serine transhydroxymethylase. Schirch L, et al. J Biol Chem, 1980 Apr 10. PMID 7358720
  4. The primary structure of rabbit liver cytosolic serine hydroxymethyltransferase. Martini F, et al. J Biol Chem, 1987 Apr 25. PMID 3553178
  5. Evidence for the in vivo deamidation and isomerization of an asparaginyl residue in cytosolic serine hydroxymethyltransferase. Artigues A, et al. J Biol Chem, 1990 Mar 25. PMID 2318867

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cobalt ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glycine hydroxymethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA 5'-UTR binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-serine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in purine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
serine hydroxymethyltransferase, cytosolic
Names
L-allo-threonine/L-threonine aldolase SHMT1
SHMT
cytosolic serine hydroxymethyltransferase
glycine hydroxymethyltransferase
serine hydroxymethyltransferase 1 (soluble)
serine methylase
NP_001095187.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101717.1 → NP_001095187.1  serine hydroxymethyltransferase, cytosolic

    See identical proteins and their annotated locations for NP_001095187.1

    Status: PROVISIONAL

    Source sequence(s)
    Z11846
    UniProtKB/Swiss-Prot
    P07511
    UniProtKB/TrEMBL
    A0A5F9C5G3
    Related
    ENSOCUP00000017814.1, ENSOCUT00000030926.3
    Conserved Domains (2) summary
    PLN03226
    Location:24 → 481
    PLN03226; serine hydroxymethyltransferase; Provisional
    pfam00464
    Location:26 → 425
    SHMT; Serine hydroxymethyltransferase

RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091448.1 Reference mOryCun1.1

    Range
    62193284..62217249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07511.2 GenPept UniProtKB/Swiss-Prot:P07511

Gene LinkOut

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Molecular Biology Databases
Research Materials