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APOE apolipoprotein E [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009337, updated on 5-Sep-2025
Gene symbol
APOE
Gene description
apolipoprotein E
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
all
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Try the new Transcripts and proteins table
See APOE in Genome Data Viewer
Location:
chromosome: 18
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 18 NC_091449.1 (11764274..11766697, complement)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026257127.1 (184211..186735, complement)

Chromosome 18 - NC_091449.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein C4 Neighboring gene apolipoprotein C1 Neighboring gene translocase of outer mitochondrial membrane 40 Neighboring gene nectin cell adhesion molecule 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix. Beierfuß A, et al. PLoS One, 2019. PMID 31751427, Free PMC Article
  2. Efficient creation of an APOE knockout rabbit. Ji D, et al. Transgenic Res, 2015 Apr. PMID 25216764
  3. Isolation and characterization of a full-length rabbit apolipoprotein E cDNA. Hao QL, et al. Atherosclerosis, 1987 Jul. PMID 3632744
  4. Apolipoprotein-E forms dimers in human frontal cortex and hippocampus. Elliott DA, et al. BMC Neurosci, 2010 Feb 20. PMID 20170526, Free PMC Article
  5. LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit. Carlucci A, et al. J Physiol Biochem, 2012 Dec. PMID 22562159

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study showed that premature intervertebral disc (IVD) degeneration in APOE-knockout rabbits was promoted by the accumulation of selective inflammatory catabolic factors that enhanced imbalances between catabolic and anabolic factors mimicking the symptoms of advanced IVD degeneration in humans. Thus, APOE-knockout rabbits could be used as a promising model for human degenerative disc disorders.
    Title: APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix.
  2. we report the efficient creation of an APOE knockout rabbit by using zinc finger nucleases. The knockout rabbits had drastically elevated cholesterol and moderately increased triglyceride levels, mimicking symptoms in human heart disease.
    Title: Efficient creation of an APOE knockout rabbit.
  3. These differentially expressed proteins associated with key mechanisms involved in atherosclerosis and signaling mechanisms related with vitamin E.
    Title: Identification of differentially expressed proteins in atherosclerotic aorta and effect of vitamin E.
  4. The molar ratio ApoE/ApoA-I is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
    Title: LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit.
  5. ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity
    Title: ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity.
  6. The identification of disulphide-linked apoE dimers in cortical and hippocampal tissues represents a distinct structural difference between the apoE3 and apoE4 isoforms that may have functional consequences.
    Title: Apolipoprotein-E forms dimers in human frontal cortex and hippocampus.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables very-low-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cholesterol catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipoprotein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of nitric-oxide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of amyloid-beta clearance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of intermediate-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
apolipoprotein E
Names
apo-E
apolipoprotein E4
NP_001076112.1

Length

  • 311

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082643.1 → NP_001076112.1  apolipoprotein E precursor

    See identical proteins and their annotated locations for NP_001076112.1

    Status: PROVISIONAL

    Source sequence(s)
    M36603
    UniProtKB/Swiss-Prot
    P18287
    Conserved Domains (1) summary
    pfam01442
    Location:80 → 244
    Apolipoprotein; Apolipoprotein A1/A4/E domain

RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091449.1 Reference mOryCun1.1

    Range
    11764274..11766697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051828487.2 → XP_051684447.2  apolipoprotein E isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18287.1 GenPept UniProtKB/Swiss-Prot:P18287

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials