MAP2K1 mitogen-activated protein kinase kinase 1 [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: MAP2K1
Gene description: mitogen-activated protein kinase kinase 1
See related: Ensembl:ENSOCUG00000008782
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_11	current	mOryCun1.1 (GCF_964237555.1)	12	NC_091443.1 (89382148..89408720)
RS_2023_02	previous assembly	UM_NZW_1.0 (GCF_009806435.1)	17	NC_067390.1 (6903041..6929866, complement)

Chromosome 12 - NC_091443.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular signal-regulated kinase (ERK) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.
Title: Salinomycin causes dedifferentiation via the extracellular signal-regulated kinase (ERK) pathway in rabbit articular chondrocytes.
KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans
Title: A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: dual specificity mitogen-activated protein kinase kinase 1

Names: ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1; MAPKK 1; MEK 1; MEK1

NP_001076098.1

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082629.1 → NP_001076098.1 dual specificity mitogen-activated protein kinase kinase 1

See identical proteins and their annotated locations for NP_001076098.1

Status: PROVISIONAL

Source sequence(s)

Z30163

UniProtKB/Swiss-Prot

P29678

UniProtKB/TrEMBL

A0A5F9C5E9

Related

ENSOCUP00000029057.1, ENSOCUT00000035942.1

Conserved Domains (2) summary

smart00220
Location:68 → 361

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06650
Location:62 → 380

PKc_MEK1; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1