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CD4 CD4 molecule [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009152, updated on 5-Sep-2025
Gene symbol
CD4
Gene description
CD4 molecule
See related
Ensembl:ENSOCUG00000012911
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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See CD4 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 9 NC_091440.1 (102704345..102730473, complement)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 8 NC_067381.1 (78804377..78828213, complement)

Chromosome 9 - NC_091440.1Genomic Context describing neighboring genes Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein-coupled receptor 162 Neighboring gene lymphocyte activating 3 Neighboring gene parathymosin Neighboring gene myeloid leukemia factor 2

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. CD4 and its role in infection of rabbit cell lines by human immunodeficiency virus type 1. Hague BF, et al. Proc Natl Acad Sci U S A, 1992 Sep 1. PMID 1518821, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MHC class II protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in interleukin-15-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
T-cell surface glycoprotein CD4
Names
T-cell surface antigen T4/Leu-3
cell surface glycoprotein CD4

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082313.2 → NP_001075782.1  T-cell surface glycoprotein CD4 precursor

    See identical proteins and their annotated locations for NP_001075782.1

    Status: PROVISIONAL

    Source sequence(s)
    M92840
    UniProtKB/Swiss-Prot
    P46630
    UniProtKB/TrEMBL
    G1T4B9
    Related
    ENSOCUP00000011113.2, ENSOCUT00000012911.4
    Conserved Domains (5) summary
    smart00410
    Location:28 → 126
    IG_like; Immunoglobulin like
    pfam05790
    Location:129 → 208
    C2-set; Immunoglobulin C2-set domain
    pfam09191
    Location:213 → 317
    CD4-extracel; CD4, extracellular
    pfam12104
    Location:427 → 454
    Tcell_CD4_C; T cell CD4 receptor C terminal region
    cl11960
    Location:28 → 125
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091440.1 Reference mOryCun1.1

    Range
    102704345..102730473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46630.1 GenPept UniProtKB/Swiss-Prot:P46630

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials