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CKM creatine kinase, M-type [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009056, updated on 5-Sep-2025
Gene symbol
CKM
Gene description
creatine kinase, M-type
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
CPK-M
Orthologs
human mouse all
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See CKM in Genome Data Viewer
Location:
chromosome: 18
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 18 NC_091449.1 (11500043..11507158)

Chromosome 18 - NC_091449.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 13 like Neighboring gene ERCC excision repair 2, TFIIH core complex helicase subunit Neighboring gene kinesin light chain 3 Neighboring gene microtubule affinity regulating kinase 4 Neighboring gene exocyst complex component 3 like 2

Genomic Sequence:
NC_091449.1 Chromosome 18 Reference mOryCun1.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Kinetic analysis of the transphosphorylation with creatine kinase by pressure-assisted capillary electrophoresis/dynamic frontal analysis. Mine M, et al. Anal Bioanal Chem, 2021 Feb. PMID 33479817
  2. The activity of carp muscle-specific creatine kinase at low temperature is enhanced by decreased hydrophobicity of residue 268. Wu CL, et al. Physiol Biochem Zool, 2014 Jul-Aug. PMID 24940915
  3. Chaperone-like effect of the linker on the isolated C-terminal domain of rabbit muscle creatine kinase. Chen Z, et al. Biophys J, 2012 Aug 8. PMID 22947872, Free PMC Article
  4. Activity and function of rabbit muscle-specific creatine kinase at low temperature by mutation at gly268 to asn268. Wu CL, et al. Comp Biochem Physiol B Biochem Mol Biol, 2011 Mar. PMID 21130895
  5. Mitochondrial creatine kinase interaction with heterogeneous monolayers: Effect on lipid lateral organization. Vernoux N, et al. Biochimie, 2009 Jun. PMID 19341780

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinetic analysis of the transphosphorylation with creatine kinase by pressure-assisted capillary electrophoresis/dynamic frontal analysis.
    Title: Kinetic analysis of the transphosphorylation with creatine kinase by pressure-assisted capillary electrophoresis/dynamic frontal analysis.
  2. water molecules affect protein conformation around residue 268, thereby influencing protein stability at low temperature
    Title: The activity of carp muscle-specific creatine kinase at low temperature is enhanced by decreased hydrophobicity of residue 268.
  3. role of linker on the isolated C-terminal domain of rabbit muscle creatine kinase
    Title: Chaperone-like effect of the linker on the isolated C-terminal domain of rabbit muscle creatine kinase.
  4. when gly(268) in rabbit muscle-specific creatine kinase was substituted with asn(268), the rabbit muscle-specific CK G286N mutant specific activity at pH 8.0 and 10 degrees C was more than 2-fold higher than that in the wild-type rabbit enzyme
    Title: Activity and function of rabbit muscle-specific creatine kinase at low temperature by mutation at gly268 to asn268.
  5. Study work provides evidence that the presence at the air/water interface of discrete domains with increased charge density, may lead to difference in partition of soluble proteins such as mtCK, interacting with the lipid monolayer.
    Title: Mitochondrial creatine kinase interaction with heterogeneous monolayers: Effect on lipid lateral organization.
  6. These results suggested that the electrostatic interactions were crucial to the action of the linker in CK reactivation.
    Title: Mutation of the conserved Asp122 in the linker impedes creatine kinase reactivation and refolding.
  7. There are three conformations of CK arranged according to the "energy minimizing principle" by ligated substrates.
    Title: Creatine kinase structural changes induced by substrates.
  8. Changing the substrate specificity of creatine kinase from creatine to glycocyamine.
    Title: Changing the substrate specificity of creatine kinase from creatine to glycocyamine: evidence for a highly evolved active site.
  9. In addition to its role in the in vivo functions, the linker also played a crucial role in the stability and folding of CKM.
    Title: Role of the linker between the N- and C-terminal domains in the stability and folding of rabbit muscle creatine kinase.
  10. Creatine kinase binds more firmly to the M-band of rabbit skeletal muscle myofibrils in the presence of its substrates.
    Title: Creatine kinase binds more firmly to the M-band of rabbit skeletal muscle myofibrils in the presence of its substrates.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables creatine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphocreatine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
creatine kinase M-type
Names
M-CK
creatine kinase M chain
creatine kinase, muscle
creatine phosphokinase M-type
muscle creatine kinase
NP_001075708.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082239.1 → NP_001075708.1  creatine kinase M-type

    See identical proteins and their annotated locations for NP_001075708.1

    Status: PROVISIONAL

    Source sequence(s)
    K02831
    UniProtKB/Swiss-Prot
    P00563
    UniProtKB/TrEMBL
    G1TUS9
    Conserved Domains (1) summary
    cd00716
    Location:16 → 373
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091449.1 Reference mOryCun1.1

    Range
    11500043..11507158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00563.1 GenPept UniProtKB/Swiss-Prot:P00563

Gene LinkOut

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Research Materials