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CALR calreticulin [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009050, updated on 20-Feb-2025
Gene symbol
CALR
Gene description
calreticulin
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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See CALR in Genome Data Viewer
Location:
chromosome: 16
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 16 NC_091447.1 (62397103..62405062)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026258842.1 (10813..14630)

Chromosome 16 - NC_091447.1Genomic Context describing neighboring genes Neighboring gene glutaryl-CoA dehydrogenase Neighboring gene synaptonemal complex central element protein 2 Neighboring gene uncharacterized LOC138845641 Neighboring gene phenylalanyl-tRNA synthetase subunit alpha Neighboring gene RAD23 nucleotide excision repair protein A Neighboring gene GADD45G interacting protein 1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Protein kinase C is involved in the regulation of several calreticulin posttranslational modifications. Cristina Castañeda-Patlán M, et al. Int J Biochem Cell Biol, 2010 Jan. PMID 19800981
  2. Identification of the Zn2+ binding region in calreticulin. Baksh S, et al. FEBS Lett, 1995 Nov 27. PMID 8521965
  3. Molecular cloning of the high affinity calcium-binding protein (calreticulin) of skeletal muscle sarcoplasmic reticulum. Fliegel L, et al. J Biol Chem, 1989 Dec 25. PMID 2600080
  4. Fast-twitch and slow-twitch skeletal muscles express the same isoform of calreticulin. Fliegel L, et al. Biochem Biophys Res Commun, 1991 Jun 28. PMID 2059224
  5. Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins. Saito Y, et al. EMBO J, 1999 Dec 1. PMID 10581245, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest that protein kinase C is involved in the regulation of CRT function.
    Title: Protein kinase C is involved in the regulation of several calreticulin posttranslational modifications.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
calreticulin
Names
CRP55
ERp60
HACBP
calregulin
endoplasmic reticulum resident protein 60

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082235.1 → NP_001075704.1  calreticulin precursor

    See identical proteins and their annotated locations for NP_001075704.1

    Status: VALIDATED

    Source sequence(s)
    J05138
    UniProtKB/Swiss-Prot
    P15253
    Conserved Domains (1) summary
    pfam00262
    Location:23 → 332
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091447.1 Reference mOryCun1.1

    Range
    62397103..62405062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_070058398.1 → XP_069914499.1  calreticulin isoform X1

    UniProtKB/Swiss-Prot
    P15253
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15253.1 GenPept UniProtKB/Swiss-Prot:P15253

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials