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VEGFA vascular endothelial growth factor A [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100008899, updated on 17-Dec-2024
Gene symbol
VEGFA
Gene description
vascular endothelial growth factor A
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
VEGF; VEGFA165b
Orthologs
human mouse all
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See VEGFA in Genome Data Viewer
Location:
chromosome: 5
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 5 NC_091436.1 (126299968..126315134, complement)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 12 NC_067385.1 (122568587..122583268, complement)

Chromosome 5 - NC_091436.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC127493036 Neighboring gene uncharacterized LOC138849803 Neighboring gene uncharacterized LOC138849748 Neighboring gene uncharacterized LOC138849660 Neighboring gene mitochondrial ribosomal protein S18A

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Detection of vascular endothelial growth factor (VEGF) in moderate osteoarthritis in a rabbit model. Jansen H, et al. Ann Anat, 2012 Sep. PMID 22429866
  2. Sequential increases in capillarization and mitochondrial enzymes in low-frequency-stimulated rabbit muscle. Skorjanc D, et al. Am J Physiol, 1998 Mar. PMID 9530113
  3. Enhanced local production of vascular endothelial growth factor is not sufficient to increase peritoneal permeability to protein during acute peritonitis. Leypoldt JK, et al. Transl Res, 2007 Aug. PMID 17656333
  4. Nicotine potentiates vascular endothelial growth factor expression in balloon-injured rabbit aortas. Zhen Y, et al. Growth Factors, 2008 Oct. PMID 18651290
  5. Sustained vascular endothelial growth factor blockade by antivascular endothelial growth factor antibodies results in nonunion in the process of fracture healing in rabbits. Chu T, et al. J Trauma, 2009 Apr. PMID 19359934

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An Avascular Niche Created by Axitinib-Loaded PCL/Collagen Nanofibrous Membrane Stabilized Subcutaneous Chondrogenesis of Mesenchymal Stromal Cells.
    Title: An Avascular Niche Created by Axitinib-Loaded PCL/Collagen Nanofibrous Membrane Stabilized Subcutaneous Chondrogenesis of Mesenchymal Stromal Cells.
  2. Effects of Axial Compression and Distraction on Vascular Bud and VEGFA Expression in the Vertebral Endplate of an Ex Vivo Rabbit Spinal Motion Segment Culture Model.
    Title: Effects of Axial Compression and Distraction on Vascular Bud and VEGFA Expression in the Vertebral Endplate of an Ex Vivo Rabbit Spinal Motion Segment Culture Model.
  3. These results demonstrated that administration of anti-VEGF in the anterior chamber of rabbit affects endothelial cell survival by inducing apoptosis through alteration of NGF pathway.
    Title: In vivo antivascular endothelial growth factor treatment induces corneal endothelium apoptosis in rabbits through changes in p75NTR-proNGF pathway.
  4. MiR-145 silencing promotes bone repair of avascular necrosis of femoral head (ANFH) via upregulating VEGF, bFGF and inhibiting the bone cells apoptosis through Wnt/beta-catenin pathway
    Title: MiR-145 silencing promotes steroid-induced avascular necrosis of the femoral head repair via upregulating VEGF.
  5. ghrelin can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF and VEGFR2 expression, inhibiting the plaque content of macrophages, and reducing MCP-1 expression at an advanced stage of atherosclerosis in rabbits
    Title: Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model.
  6. VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but the level increased at 144 h in uterus.
    Title: Oviductal and endometrial mRNA expression of implantation candidate biomarkers during early pregnancy in rabbit.
  7. correlation was observed between CT perfusion parameters (BF, BV, PS, and MAV) and expression of VEGF and MVD in tumor tissue
    Title: Correlations between CT perfusion parameters and vascular endothelial growth factor expression and microvessel density in implanted VX2 lung tumors.
  8. Physiologic ischemic training stimulates VEGF-mediated mobilization of endothelial progenitor cells as well as angiogenesis.
    Title: Impact of remote physiological ischemic training on vascular endothelial growth factor, endothelial progenitor cells and coronary angiogenesis after myocardial ischemia.
  9. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
    Title: Supplemental oxygen reverses hypoxia-induced smooth muscle cell proliferation by modulating HIF-alpha and VEGF levels in a rabbit arteriovenous fistula model.
  10. Therefore, it was reasonable to speculate that the increased expression of VEGF and MMP-9 in residual hepatic tumor cells and tumor angiogenesis post-embolization would be responsible for the increased metastatic potentiality and invasiveness.
    Title: Over-expression of VEGF and MMP-9 in residual tumor cells of hepatocellular carcinoma after embolization with lipidol.
Submit: New GeneRIF Correction See all GeneRIFs (27)

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chemoattractant activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables vascular endothelial growth factor receptor 1 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables vascular endothelial growth factor receptor 2 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in induction of positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mast cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sprouting angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
vascular endothelial growth factor A, long form

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RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091436.1 Reference mOryCun1.1

    Range
    126299968..126315134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_070074064.1 → XP_069930165.1  vascular endothelial growth factor A, long form isoform X2

    UniProtKB/TrEMBL
    A0A224A9W4

  2. XM_070074062.1 → XP_069930163.1  vascular endothelial growth factor A, long form isoform X1

Nucleotide Protein
Heading Accession and Version

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Molecular Biology Databases
Research Materials