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IL6 interleukin 6 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100008733, updated on 5-Sep-2025
Gene symbol
IL6
Gene description
interleukin 6
See related
Ensembl:ENSOCUG00000027471
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
IL-6
Orthologs
human mouse all
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See IL6 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 16 NC_091447.1 (14665796..14670599)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 10 NC_067383.1 (4825832..4830644)

Chromosome 16 - NC_091447.1Genomic Context describing neighboring genes Neighboring gene probable ATP-dependent RNA helicase DDX52 Neighboring gene probable ATP-dependent RNA helicase DDX52 pseudogene Neighboring gene translocase of outer mitochondrial membrane 7 Neighboring gene small nucleolar RNA SNORD93

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Computer-assisted prediction of atherosclerotic intimal thickness based on weight of adrenal gland, interleukin-6 concentration, and neural networks. Meng LB, et al. J Int Med Res, 2020 Jan. PMID 31039661, Free PMC Article
  2. Heat effect induces production of inflammatory cytokines through heat shock protein 90 pathway in cornea cells. Tsai MJ, et al. Curr Eye Res, 2013 Apr. PMID 23330884
  3. Convergent evolution of IL-6 in two leporids (Oryctolagus and Pentalagus) originated an extended protein. Neves F, et al. Immunogenetics, 2014 Oct. PMID 25027474
  4. The complete cDNA sequences of IL-2, IL-4, IL-6 AND IL-10 from the European rabbit (Oryctolagus cuniculus). Perkins HD, et al. Cytokine, 2000 Jun. PMID 10843729
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Computer-assisted prediction of atherosclerotic intimal thickness based on weight of adrenal gland, interleukin-6 concentration, and neural networks.
    Title: Computer-assisted prediction of atherosclerotic intimal thickness based on weight of adrenal gland, interleukin-6 concentration, and neural networks.
  2. Mild heat shock increased the production of inflammatory cytokines, IL-1beta and IL-6 in rabbit cornea cells.
    Title: Heat effect induces production of inflammatory cytokines through heat shock protein 90 pathway in cornea cells.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-6 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T-helper 17 cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of interleukin-6 receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
interleukin-6
Names
interleukin 6 (interferon, beta 2)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082064.2 → NP_001075533.1  interleukin-6 precursor

    See identical proteins and their annotated locations for NP_001075533.1

    Status: PROVISIONAL

    Source sequence(s)
    AF169176
    UniProtKB/Swiss-Prot
    Q0PW36, Q9MZR1
    UniProtKB/TrEMBL
    A0A076E4H8, A0A076E693, A0A076E7W9
    Related
    ENSOCUP00000017266.1, ENSOCUT00000023601.3
    Conserved Domains (1) summary
    cl02473
    Location:29 → 211
    IL6; Interleukin-6/G-CSF/MGF family

RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091447.1 Reference mOryCun1.1

    Range
    14665796..14670599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MZR1.1 GenPept UniProtKB/Swiss-Prot:Q9MZR1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials