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KDR kinase insert domain receptor [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100008607, updated on 2-Dec-2024
Gene symbol
KDR
Gene description
kinase insert domain receptor
See related
Ensembl:ENSOCUG00000005062
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
FLK/KDR
Orthologs
human mouse all
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See KDR in Genome Data Viewer
Location:
chromosome: 8
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 8 NC_091439.1 (109262002..109321208)
RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) 15 NC_067388.1 (90460106..90525025)

Chromosome 8 - NC_091439.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS1 pseudogene Neighboring gene transmembrane protein 165 Neighboring gene steroid 5 alpha-reductase 3 Neighboring gene uncharacterized LOC138843396 Neighboring gene uncharacterized LOC138843292

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Antenatal fetal VEGF therapy to promote pulmonary maturation in a preterm rabbit model. Debeer A, et al. Early Hum Dev, 2010 Feb. PMID 20181445
  2. Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model. Wang L, et al. Peptides, 2017 Apr. PMID 28189525
  3. Small Molecular-Sized Artesunate Attenuates Ocular Neovascularization via VEGFR2, PKCα, and PDGFR Targets. Zong Y, et al. Sci Rep, 2016 Aug 2. PMID 27480521, Free PMC Article
  4. VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not PDGF-BB/PDGFR-β play important roles in promoting immature and inflammatory intraplaque angiogenesis. Mao Y, et al. PLoS One, 2018. PMID 30125282, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High expression of VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not of PDGF-BB/PDGFR-beta may contribute to immature and inflammatory intraplaque angiogenesis and plaque instability in a rabbit model of atherosclerosis.
    Title: VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not PDGF-BB/PDGFR-β play important roles in promoting immature and inflammatory intraplaque angiogenesis.
  2. High VEGFR2 expression is associated with retinal neovascularization.
    Title: Small Molecular-Sized Artesunate Attenuates Ocular Neovascularization via VEGFR2, PKCα, and PDGFR Targets.
  3. ghrelin can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF and VEGFR2 expression, inhibiting the plaque content of macrophages, and reducing MCP-1 expression at an advanced stage of atherosclerosis in rabbits
    Title: Ghrelin inhibits atherosclerotic plaque angiogenesis and promotes plaque stability in a rabbit atherosclerotic model.
  4. Antenatal intratracheal VEGF administration was associated with an increase in Flk-1 immunoreactivity.
    Title: Antenatal fetal VEGF therapy to promote pulmonary maturation in a preterm rabbit model.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables vascular endothelial growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
vascular endothelial growth factor receptor 2
Names
VEGF receptor-2/Flk-1
kinase insert domain receptor (a type III receptor tyrosine kinase)
NP_001182599.1
XP_017202732.1
XP_051675211.2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195670.2 → NP_001182599.1  vascular endothelial growth factor receptor 2 precursor

    Status: PROVISIONAL

    Source sequence(s)
    VIYN02003004
    UniProtKB/TrEMBL
    G1SN50
    Related
    ENSOCUP00000004388.3, ENSOCUT00000005066.4
    Conserved Domains (8) summary
    smart00408
    Location:680 → 744
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:231 → 324
    IG_like; Immunoglobulin like
    pfam07679
    Location:667 → 754
    I-set; Immunoglobulin I-set domain
    cd05103
    Location:826 → 1167
    PTKc_VEGFR2; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2
    pfam07714
    Location:834 → 1160
    Pkinase_Tyr; Protein tyrosine kinase
    pfam13895
    Location:551 → 657
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:427 → 482
    Ig_3; Immunoglobulin domain
    cl11960
    Location:239 → 326
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mOryCun1.1

Genomic

  1. NC_091439.1 Reference mOryCun1.1

    Range
    109262002..109321208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051819251.2 → XP_051675211.2  vascular endothelial growth factor receptor 2 isoform X1

  2. XM_017347243.3 → XP_017202732.1  vascular endothelial growth factor receptor 2 isoform X2

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials