U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

myhz1.1l myosin, heavy polypeptide 1.1, like [ Danio rerio (zebrafish) ]

Gene ID: 100008376, updated on 14-Dec-2025
Official Symbol
myhz1.1lprovided by ZNC
Official Full Name
myosin, heavy polypeptide 1.1, likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-200402-1
See related
Ensembl:ENSDARG00000102414 AllianceGenome:ZFIN:ZDB-GENE-200402-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fd14a01; myhz1.1; wu:fd14a01
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in system development. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Orthologous to human MYH1 (myosin heavy chain 1). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See myhz1.1l in Genome Data Viewer
Location:
chromosome: 22
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 22 NC_133197.1 (57346..72083)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 22 NC_007133.7 (268161..282736, complement)

Chromosome 22 - NC_133197.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141380113 Neighboring gene myosin heavy chain, fast skeletal muscle-like Neighboring gene myosin heavy chain, fast skeletal muscle-like Neighboring gene uncharacterized LOC137488988

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Calcium signaling as a possible mechanism behind increased locomotor response in zebrafish larvae exposed to a human relevant persistent organic pollutant mixture or PFOS. Christou M, et al. Environ Res, 2020 Aug. PMID 32474314
  2. SMYD1-mediated mono-methylation of lysine K35 of sarcomeric myosin heavy chain (MHC) regulates sarcomere assembly and homeostasis in zebrafish and human iPSC-derived cardiomyocytes. Diofano F, et al. J Mol Cell Cardiol, 2025 Nov. PMID 40972758
  3. Thyroid hormone regulates muscle function during cold acclimation in zebrafish (Danio rerio). Little AG, et al. J Exp Biol, 2013 Sep 15. PMID 23966591
  4. Duplication of a Single myhz1.1 Gene Facilitated the Ability of Goldfish (Carassius auratus) to Alter Fast Muscle Contractile Properties With Seasonal Temperature Change. Garcia de la Serrana D, et al. Front Physiol, 2018. PMID 30568597, Free PMC Article
  5. Hypoxia-inducible factor 3 is an oxygen-dependent transcription activator and regulates a distinct transcriptional response to hypoxia. Zhang P, et al. Cell Rep, 2014 Mar 27. PMID 24613356

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
  
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in system development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myofibril IEA
Inferred from Electronic Annotation
more info
  
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in myosin filament IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
myosin-4; myosin heavy chain, fast skeletal muscle
Names
FMHC

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133197.1 Reference GRCz12tu Primary Assembly

    Range
    57346..72083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469469.3 → XP_021325144.1  myosin heavy chain, fast skeletal muscle

    UniProtKB/TrEMBL
    A0A8M9PJW6, A0AB32TF38
    Related
    ENSDARP00000088845.5
    Conserved Domains (3) summary
    cd01377
    Location:99 → 768
    MYSc_class_II; class II myosins, motor domain
    pfam02736
    Location:34 → 72
    Myosin_N; Myosin N-terminal SH3-like domain
    cl25732
    Location:848 → 1925
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools