abcb10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abcb10provided by ZNC
Official Full Name: ATP-binding cassette, sub-family B (MDR/TAP), member 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-040525-2
See related: Ensembl:ENSDARG00000061591 AllianceGenome:ZFIN:ZDB-GENE-040525-2
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-162b3.3
Summary: Enables ATP hydrolysis activity. Involved in positive regulation of heme biosynthetic process. Acts upstream of or within erythrocyte differentiation. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Is expressed in kidney. Orthologous to human ABCB10 (ATP binding cassette subfamily B member 10). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	13	NC_133188.1 (27449175..27463290)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (24262705..24276812)

Chromosome 13 - NC_133188.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables ABC-type oligopeptide transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligopeptide export from mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hemoglobin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_001343182.10 → XP_001343218.3 ATP-binding cassette sub-family B member 10, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8M1Q250, F1Q5K6

Related

ENSDARP00000082438.3

Conserved Domains (3) summary

TIGR02204
Location:123 → 697

MsbA_rel; ABC transporter, permease/ATP-binding protein

pfam00664
Location:141 → 402

ABC_membrane; ABC transporter transmembrane region

cl21455
Location:457 → 697

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
XM_073920892.1 → XP_073776993.1 ATP-binding cassette sub-family B member 10, mitochondrial isoform X2