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ciita class II, major histocompatibility complex, transactivator [ Danio rerio (zebrafish) ]

Gene ID: 100003537, updated on 9-Sep-2025
Official Symbol
ciitaprovided by ZNC
Official Full Name
class II, major histocompatibility complex, transactivatorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-071116-6
See related
Ensembl:ENSDARG00000090851 AllianceGenome:ZFIN:ZDB-GENE-071116-6
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CIITAv1; CIITAv2
Summary
Predicted to enable ATP binding activity. Predicted to be involved in positive regulation of MHC class I biosynthetic process; positive regulation of MHC class II biosynthetic process; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
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See ciita in Genome Data Viewer
Location:
chromosome: 3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 3 NC_133178.1 (25649210..25670631, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 3 NC_007114.7 (26908977..26931556, complement)

Chromosome 3 - NC_133178.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain containing 16A Neighboring gene Dexi homolog (mouse) Neighboring gene nucleotide binding protein 1 (MinD homolog, E. coli) Neighboring gene uncharacterized LOC141381205

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Structure and evolutionary history of a large family of NLR proteins in the zebrafish. Howe K, et al. Open Biol, 2016 Apr. PMID 27248802, Free PMC Article
  2. Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: insights into the basic mechanisms of protection seen in immunized fish. Yang D, et al. Dev Comp Immunol, 2013 Jun. PMID 23434462
  3. RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. Yang D, et al. BMC Genomics, 2012 Jul 17. PMID 22805612, Free PMC Article
  4. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. Liongue C, et al. PLoS One, 2012. PMID 22412924, Free PMC Article
  5. Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. Stein C, et al. Genome Biol, 2007. PMID 18039395, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of MHC class I biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MHC class II biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
MHC class II transactivator
XP_001343072.2
XP_005163972.1
XP_009297712.1
XP_073800622.1

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RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133178.1 Reference GRCz12tu Primary Assembly

    Range
    25649210..25670631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005163915.6 → XP_005163972.1  MHC class II transactivator isoform X2

    UniProtKB/TrEMBL
    A0A8M2BB20
    Conserved Domains (4) summary
    cd00116
    Location:801 → 1117
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:998 → 1025
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:969 → 982
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl21455
    Location:424 → 593
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_009299437.5 → XP_009297712.1  MHC class II transactivator isoform X1

    UniProtKB/TrEMBL
    A0A8M3AQW0
    Conserved Domains (4) summary
    cd00116
    Location:806 → 1122
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:1003 → 1030
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:974 → 987
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl21455
    Location:429 → 598
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_073944521.1 → XP_073800622.1  MHC class II transactivator isoform X4

  4. XM_001343036.8 → XP_001343072.2  MHC class II transactivator isoform X3

    UniProtKB/TrEMBL
    A0A8M1PV63, E7F3F4
    Related
    ENSDARP00000105957.1
    Conserved Domains (4) summary
    cd00116
    Location:707 → 1023
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:904 → 931
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:875 → 888
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl21455
    Location:330 → 499
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
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