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grin2ca glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca [ Danio rerio (zebrafish) ]

Gene ID: 100003342, updated on 6-Jul-2026
Official Symbol
grin2caprovided by ZNC
Official Full Name
glutamate receptor, ionotropic, N-methyl D-aspartate 2Caprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070822-3
See related
Ensembl:ENSDARG00000078149 AllianceGenome:ZFIN:ZDB-GENE-070822-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
NR2C.1; ZN2C.1; grin2c
Summary
Predicted to enable NMDA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential; glutamatergic synaptic transmission; and long-term synaptic potentiation. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Orthologous to human GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See grin2ca in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 3 NC_133178.1 (17788491..17918091, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 3 NC_007114.7 (19004576..19133834, complement)

Chromosome 3 - NC_133178.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 38 member 12 Neighboring gene si:ch211-198m1.1 Neighboring gene uncharacterized LOC137490529 Neighboring gene regulatory factor X, 1a (influences HLA class II expression) Neighboring gene interleukin 12 receptor, beta 2a, like Neighboring gene relaxin 3a

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Evaluation of age-dependent response to NMDA receptor antagonism in zebrafish. Menezes FP, et al. Zebrafish, 2015 Apr. PMID 25602300
  2. Molecular characterization and embryonic expression of the family of N-methyl-D-aspartate receptor subunit genes in the zebrafish. Cox JA, et al. Dev Dyn, 2005 Nov. PMID 16123982
  3. Evolution of Class I cytokine receptors. Liongue C, et al. BMC Evol Biol, 2007 Jul 18. PMID 17640376, Free PMC Article
  4. Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. Sato Y, et al. BMC Evol Biol, 2009 Jun 5. PMID 19500364, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NMDA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NMDA glutamate receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in excitatory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in long-term synaptic potentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NMDA selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NMDA selective glutamate receptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca
Names
glutamate receptor, ionotropic, N-methyl D-aspartate 2C

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365787.1 → NP_001352716.1  glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca precursor

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000003
    UniProtKB/TrEMBL
    A0A8M1RQV2, E7FH62, F6PCG7
    Related
    ENSDARP00000113160.1, ENSDART00000145215.2
    Conserved Domains (3) summary
    cd06378
    Location:38 → 398
    PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
    cd13718
    Location:409 → 810
    PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    pfam10565
    Location:847 → 938
    NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133178.1 Reference GRCz12tu Primary Assembly

    Range
    17788491..17918091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177462.1: Suppressed sequence

    Description
    NM_001177462.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: GRIN2C (GeneID:2905).
Nucleotide Protein Strain
Heading Accession and Version

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