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tafa5a TAFA chemokine like family member 5a [ Danio rerio (zebrafish) ]

Gene ID: 100002919, updated on 6-Jul-2026
Official Symbol
tafa5aprovided by ZNC
Official Full Name
TAFA chemokine like family member 5aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-344
See related
Ensembl:ENSDARG00000069160 AllianceGenome:ZFIN:ZDB-GENE-041210-344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sam5a; fam19a5; fam19a5a; si:dkey-200m9.1; si:dkey-27f18.1; si:dkey-164m14.8
Summary
Predicted to enable G protein-coupled receptor binding activity and receptor ligand activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in brain. Orthologous to human TAFA5 (TAFA chemokine like family member 5). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See tafa5a in Genome Data Viewer
Location:
chromosome: 4
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 4 NC_133179.1 (29008678..29156453, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 4 NC_007115.7 (27251865..27399210, complement)

Chromosome 4 - NC_133179.1Genomic Context describing neighboring genes Neighboring gene zinc finger, BED-type containing 4 Neighboring gene bromodomain containing 1a Neighboring gene TBC1 domain family, member 22a Neighboring gene uncharacterized LOC141381639 Neighboring gene ceramide kinase

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. FAM19A5l Affects Mustard Oil-Induced Peripheral Nociception in Zebrafish. Jeong I, et al. Mol Neurobiol, 2021 Sep. PMID 34176096
  2. The Neuropeptide Fam19a5a/tafa5a Regulates Inflammation and Influences Anxiety-Like Behaviours in Zebrafish. Jeong I, et al. Eur J Neurosci, 2026 Jan. PMID 41532371
  3. Targeted knockout of a chemokine-like gene increases anxiety and fear responses. Choi JH, et al. Proc Natl Acad Sci U S A, 2018 Jan 30. PMID 29339520, Free PMC Article
  4. A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Varshney GK, et al. Genome Res, 2013 Apr. PMID 23382537, Free PMC Article
  5. Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Wang D, et al. Proc Natl Acad Sci U S A, 2007 Jul 24. PMID 17640903, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
chemokine-like protein TAFA-5a
Names
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
family with sequence similarity 19 (chemokine (C-C motif)-like), member A5a
family with sequence similarity 19 member A5, C-C motif chemokine like a

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430368.2 → NP_001417297.1  chemokine-like protein TAFA-5a isoform 1

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000004
    UniProtKB/TrEMBL
    A0A2R8QIB8, A0A8M2BFW6
    Related
    ENSDARP00000125559.1, ENSDART00000142117.4

  2. NM_001430369.2 → NP_001417298.1  chemokine-like protein TAFA-5a isoform 2

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000004
    UniProtKB/TrEMBL
    A0AB13ABS6

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133179.1 Reference GRCz12tu Primary Assembly

    Range
    29008678..29156453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168536.6 → XP_005168593.1  chemokine-like protein TAFA-5a isoform X1

    UniProtKB/TrEMBL
    A0A8M2BFV2, H0WEJ8
    Related
    ENSDARP00000125276.1
    Conserved Domains (1) summary
    pfam12020
    Location:42 → 131
    TAFA; TAFA family

  2. XM_005168537.6 → XP_005168594.1  chemokine-like protein TAFA-5a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BFV3, A2BIC8
    Related
    ENSDARP00000114783.1
    Conserved Domains (1) summary
    pfam12020
    Location:41 → 130
    TAFA; TAFA family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001122744.1: Suppressed sequence

    Description
    NM_001122744.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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