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cyfip2 cytoplasmic FMR1 interacting protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 100002872, updated on 30-May-2026
Official Symbol
cyfip2provided by ZNC
Official Full Name
cytoplasmic FMR1 interacting protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-080724-2
See related
Ensembl:ENSDARG00000036375 AllianceGenome:ZFIN:ZDB-GENE-080724-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:194528
Summary
Predicted to enable small GTPase binding activity. Acts upstream of or within with a positive effect on retinal ganglion cell axon guidance. Acts upstream of or within retina layer formation and startle response. Predicted to be located in cytoplasm. Predicted to be active in neuron projection and synapse. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 65. Orthologous to human CYFIP2 (cytoplasmic FMR1 interacting protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
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See cyfip2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 14 NC_133189.1 (38561082..38621138, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 14 NC_007125.7 (33984355..34044416, complement)

Chromosome 14 - NC_133189.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101882840 Neighboring gene forkhead box A sequence Neighboring gene IL2 inducible T cell kinase Neighboring gene LON peptidase N-terminal domain and ring finger 4 Neighboring gene mediator complex subunit 7

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold. Marsden KC, et al. Cell Rep, 2018 Apr 17. PMID 29669291, Free PMC Article
  2. Inactivating negative regulators of cortical branched actin enhances persistence of single cell migration. Fokin AI, et al. J Cell Sci, 2024 Jan 1. PMID 38059420
  3. Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function. Cioni JM, et al. Neuron, 2018 Mar 7. PMID 29518358, Free PMC Article
  4. nev (cyfip2) is required for retinal lamination and axon guidance in the zebrafish retinotectal system. Pittman AJ, et al. Dev Biol, 2010 Aug 15. PMID 20537992, Free PMC Article
  5. Knockout of bcas3 gene causes neurodevelopment defects in zebrafish. Liu H, et al. Biol Res, 2025 Jun 6. PMID 40481608, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cyfip2 regulates the innate startle threshold by reducing neural activity in a small group of excitatory hindbrain interneurons.
    Title: A Cyfip2-Dependent Excitatory Interneuron Pathway Establishes the Innate Startle Threshold.
  2. CYFIP2's function in axon sorting is mediated by its binding to the WAVE regulatory complex, but not its translational regulation.
    Title: Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function.
  3. cyfip2 is required for retinal lamination and axon guidance in the zebrafish retinotectal system.
    Title: nev (cyfip2) is required for retinal lamination and axon guidance in the zebrafish retinotectal system.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
NOT enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina layer formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within_positive_effect retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within startle response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
NOT part_of SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
cytoplasmic FMR1-interacting protein 2
Names
nev
nevermind

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097587.2 → NP_001091056.2  cytoplasmic FMR1-interacting protein 2

    Status: VALIDATED

    Source sequence(s)
    JBMGRA010000014
    UniProtKB/TrEMBL
    A0A8M3AHW5, A0AC58H587, B3DIT1
    Related
    ENSDARP00000106311.1, ENSDART00000123607.2

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133189.1 Reference GRCz12tu Primary Assembly

    Range
    38561082..38621138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_073921058.1 → XP_073777159.1  cytoplasmic FMR1-interacting protein 2 isoform X4

    UniProtKB/TrEMBL
    A0AC58H5A8

  2. XM_073921057.1 → XP_073777158.1  cytoplasmic FMR1-interacting protein 2 isoform X3

    UniProtKB/TrEMBL
    A0AC58H598

  3. XM_073921056.1 → XP_073777157.1  

  4. XM_073921055.1 → XP_073777156.1  cytoplasmic FMR1-interacting protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M1NEL2, A0AC58H592, A5A5E1

  5. XM_073921059.1 → XP_073777160.1  cytoplasmic FMR1-interacting protein 2 isoform X5

    UniProtKB/TrEMBL
    A0AC58H5B8

RNA

  1. XR_012389356.1 RNA Sequence

  2. XR_012389355.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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