U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

apcdd1l adenomatosis polyposis coli down-regulated 1-like [ Danio rerio (zebrafish) ]

Gene ID: 100001408, updated on 6-Jul-2026
Official Symbol
apcdd1lprovided by ZNC
Official Full Name
adenomatosis polyposis coli down-regulated 1-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-121022-3
See related
Ensembl:ENSDARG00000075557 AllianceGenome:ZFIN:ZDB-GENE-121022-3
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable Wnt-protein binding activity. Acts upstream of or within glial cell development and retina development in camera-type eye. Predicted to be located in plasma membrane. Is expressed in several structures, including atrium; brain; corpuscles of Stannius; eye; and post-vent region. Orthologous to human APCDD1L (APC down-regulated 1 like). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See apcdd1l in Genome Data Viewer
Location:
chromosome: 6
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 6 NC_133181.1 (52285379..52307924, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 6 NC_007117.7 (49650873..49673446, complement)

Chromosome 6 - NC_133181.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141386362 Neighboring gene RAB22A, member RAS oncogene family Neighboring gene VAMP (vesicle-associated membrane protein)-associated protein B and C Neighboring gene uncharacterized LOC141386361 Neighboring gene syntaxin 16 Neighboring gene aminopeptidase like 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin. Vonica A, et al. Dev Biol, 2020 Aug 1. PMID 32320685, Free PMC Article
  2. Corpuscles of Stannius development requires FGF signaling. Klingbeil K, et al. Dev Biol, 2022 Jan. PMID 34666023
  3. Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate. Burkhard SB, et al. Elife, 2018 Feb 5. PMID 29400650, Free PMC Article
  4. Genetic control of cellular morphogenesis in Müller glia. Charlton-Perkins M, et al. Glia, 2019 Jul. PMID 30924555, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within glial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein APCDD1-like

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133181.1 Reference GRCz12tu Primary Assembly

    Range
    52285379..52307924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021471845.3 → XP_021327520.2  protein APCDD1-like

    UniProtKB/TrEMBL
    A0A8M9Q271
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials