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appl2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 [ Danio rerio (zebrafish) ]

Gene ID: 100000135, updated on 22-Nov-2020

Summary

Official Symbol
appl2provided by ZNC
Official Full Name
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-081016-2
See related
Ensembl:ENSDARG00000078139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Orthologs

Genomic context

See appl2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (5790536..5815865, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (5664029..5689359, complement)
103 previous assembly Zv9 (GCF_000002035.4) 25 NC_007136.5 (6028149..6053464, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 3 beta 2 subunit Neighboring gene tubulin, gamma complex associated protein 6 Neighboring gene chromosome 25 C12orf75 homolog Neighboring gene uncharacterized LOC103909811

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
gamma-tubulin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
microtubule nucleation IEA
Inferred from Electronic Annotation
more info
 
signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
endosome IGI
Inferred from Genetic Interaction
more info
PubMed 
endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
ruffle IEA
Inferred from Electronic Annotation
more info
 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DCC-interacting protein 13-beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128075.1NP_001121547.1  DCC-interacting protein 13-beta

    See identical proteins and their annotated locations for NP_001121547.1

    Status: PROVISIONAL

    Source sequence(s)
    EU053153
    UniProtKB/TrEMBL
    B2XCM0
    Conserved Domains (4) summary
    cd13158
    Location:488614
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:253375
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
    pfam00169
    Location:277377
    PH; PH domain
    cl12013
    Location:21235
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    5790536..5815865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005174259.4XP_005174316.1  DCC-interacting protein 13-beta isoform X1

    UniProtKB/TrEMBL
    F1RB27
    Related
    ENSDARP00000101503.2, ENSDART00000112853.4
    Conserved Domains (4) summary
    cd07632
    Location:21235
    BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
    cd13158
    Location:488614
    PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
    cd13247
    Location:253375
    BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
    pfam00169
    Location:277377
    PH; PH domain
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