Format

Send to:

Choose Destination

SELPLG selectin P ligand [ Homo sapiens (human) ]

Gene ID: 6404, updated on 12-Oct-2019

Summary

Official Symbol
SELPLGprovided by HGNC
Official Full Name
selectin P ligandprovided by HGNC
Primary source
HGNC:HGNC:10722
See related
Ensembl:ENSG00000110876 MIM:600738
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLA; CD162; PSGL1; PSGL-1
Summary
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
Expression
Broad expression in spleen (RPKM 29.0), lymph node (RPKM 26.4) and 22 other tissues See more
Orthologs

Genomic context

See SELPLG in Genome Data Viewer
Location:
12q24.11
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (108621895..108633894, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (109015671..109027735, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene transmembrane protein 119 Neighboring gene uncharacterized LOC105369968 Neighboring gene microRNA 4496 Neighboring gene coronin 1C Neighboring gene RNA, U7 small nuclear 169 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog
Genome-wide association study of conduct disorder symptomatology.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CD3/CD28-activated primary CD4+ T cells downregulates plasma membrane expression of SELPLG (CD162, PSGL1) PubMed
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of SELPLG PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Basic sequences in the cytoplasmic domains of PSGL-1, CD43, and CD44 are required for efficient association with HIV-1 Gag in HeLa cells PubMed
gag The highly basic region (HBR) of HIV-1 MA promotes Gag association with specific UDMs containing PSGL-1, CD43, and CD59 PubMed
gag HIV-1 Gag multimers associate with a specific subset of uropod-directed microdomains (UDMs) containing PSGL-1, CD43, and CD44 PubMed
gag HIV-1 Gag co-localizes with both uropod markers PSGL-1 and CD43 on the plasma membrane PubMed
Vpu vpu HIV-1 Vpu downregulates the cell surface expression of selectin P ligand (SELPLG, CD162) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
    Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • Staphylococcus aureus infection, conserved biosystem (from KEGG)
    Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
  • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
    amb2 Integrin signaling, organism-specific biosystem
    amb2 Integrin signaling

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cellular response to interleukin-6 IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte adhesive activation ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
leukocyte tethering or rolling IDA
Inferred from Direct Assay
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
uropod IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
P-selectin glycoprotein ligand 1
Names
cutaneous lymphocyte-associated associated antigen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206609.2NP_001193538.1  P-selectin glycoprotein ligand 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007569, AC008119, AK298742, BC029782, CA427270, DC339004
    Consensus CDS
    CCDS55881.1
    UniProtKB/Swiss-Prot
    Q14242
    Related
    ENSP00000228463.6, ENST00000228463.6
    Conserved Domains (1) summary
    PRK10811
    Location:136295
    rne; ribonuclease E; Reviewed
  2. NM_003006.4NP_002997.2  P-selectin glycoprotein ligand 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_002997.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008119, AK098315, AK225644
    Consensus CDS
    CCDS31895.2
    UniProtKB/Swiss-Prot
    Q14242
    Related
    ENSP00000447752.1, ENST00000550948.1
    Conserved Domains (1) summary
    PRK10811
    Location:120279
    rne; ribonuclease E; Reviewed

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    108621895..108633894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center