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IL22 interleukin 22 [ Homo sapiens (human) ]

Gene ID: 50616, updated on 28-Nov-2021

Summary

Official Symbol
IL22provided by HGNC
Official Full Name
interleukin 22provided by HGNC
Primary source
HGNC:HGNC:14900
See related
Ensembl:ENSG00000127318 MIM:605330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23
Summary
This gene is a member of the IL10 family of cytokines that mediate cellular inflammatory responses. The encoded protein functions in antimicrobial defense at mucosal surfaces and in tissue repair. This protein also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases. [provided by RefSeq, Jul 2018]
Annotation information
Note: This gene (GeneID: 50616) was identified as IL-21 or IL-TIF in PMID: 10954742. The official symbol for this gene is now IL22. [19 May 2011]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IL22 in Genome Data Viewer
Location:
12q15
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (68248242..68253604, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (68642022..68647384, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene interferon gamma Neighboring gene uncharacterized LOC105369818 Neighboring gene interleukin 26 Neighboring gene Mdm1 nuclear protein Neighboring gene uncharacterized LOC105369819

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC79382, MGC79384

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-22 receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in acute-phase response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-22
Names
IL-10-related T-cell-derived inducible factor
cytokine Zcyto18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_060763.1 RefSeqGene

    Range
    5001..10363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1248

mRNA and Protein(s)

  1. NM_020525.5NP_065386.1  interleukin-22 precursor

    See identical proteins and their annotated locations for NP_065386.1

    Status: REVIEWED

    Source sequence(s)
    BC070261, CD638517
    Consensus CDS
    CCDS8982.1
    UniProtKB/Swiss-Prot
    Q9GZX6
    Related
    ENSP00000442424.1, ENST00000538666.6
    Conserved Domains (1) summary
    pfam14565
    Location:40178
    IL22; Interleukin 22 IL-10-related T-cell-derived-inducible factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    68248242..68253604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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