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IL5 interleukin 5 [ Homo sapiens (human) ]

Gene ID: 3567, updated on 23-Nov-2021

Summary

Official Symbol
IL5provided by HGNC
Official Full Name
interleukin 5provided by HGNC
Primary source
HGNC:HGNC:6016
See related
Ensembl:ENSG00000113525 MIM:147850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDF; TRF; IL-5
Summary
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IL5 in Genome Data Viewer
Location:
5q31.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (132539194..132556864, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (131877137..131879214, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene IRF1 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 2863 Neighboring gene interferon regulatory factor 1 Neighboring gene RAD50 double strand break repair protein Neighboring gene Th2 cytokine locus control region Neighboring gene T helper type 2 locus control region associated RNA Neighboring gene interleukin 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-5 receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
interleukin-5
Names
B-cell differentiation factor I
T-cell replacing factor
colony-stimulating factor, eosinophil
eosinophil differentiation factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033019.1 RefSeqGene

    Range
    5001..7078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000879.3NP_000870.1  interleukin-5 precursor

    See identical proteins and their annotated locations for NP_000870.1

    Status: REVIEWED

    Source sequence(s)
    AC116366
    Consensus CDS
    CCDS4156.1
    UniProtKB/Swiss-Prot
    P05113
    Related
    ENSP00000231454.1, ENST00000231454.6
    Conserved Domains (1) summary
    pfam02025
    Location:22133
    IL5; Interleukin 5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    132539194..132556864 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271988.4XP_005272045.1  interleukin-5 isoform X1

    Conserved Domains (1) summary
    pfam02025
    Location:44155
    IL5; Interleukin 5
  2. XM_011543374.3XP_011541676.1  interleukin-5 isoform X2

    See identical proteins and their annotated locations for XP_011541676.1

    UniProtKB/Swiss-Prot
    P05113
    Conserved Domains (1) summary
    pfam02025
    Location:22133
    IL5; Interleukin 5
  3. XM_011543373.3XP_011541675.1  interleukin-5 isoform X2

    See identical proteins and their annotated locations for XP_011541675.1

    UniProtKB/Swiss-Prot
    P05113
    Conserved Domains (1) summary
    pfam02025
    Location:22133
    IL5; Interleukin 5
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