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Foxp3 forkhead box P3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317382, updated on 8-Dec-2022

Summary

Official Symbol
Foxp3provided by RGD
Official Full Name
forkhead box P3provided by RGD
Primary source
RGD:1562112
See related
Ensembl:ENSRNOG00000011702 AllianceGenome:RGD:1562112
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562112
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; NFAT protein binding activity; and enzyme binding activity. Involved in several processes, including establishment of endothelial blood-brain barrier; negative regulation of defense response to virus; and response to rapamycin. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Used to study intrahepatic cholangiocarcinoma. Biomarker of Korean hemorrhagic fever; asthma; bronchiolitis obliterans; hypertension; and hypothyroidism. Human ortholog(s) of this gene implicated in Human papillomavirus infectious disease; colorectal cancer; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human FOXP3 (forkhead box P3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 46.7), Thymus (RPKM 33.3) and 9 other tissues See more
Orthologs
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Genomic context

See Foxp3 in Genome Data Viewer
Location:
Xq12
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14908494..14924994, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15753175..15768648, complement)

Chromosome X - NC_051356.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099258 Neighboring gene synaptophysin Neighboring gene calcium voltage-gated channel subunit alpha1 F Neighboring gene coiled-coil domain containing 22 Neighboring gene uncharacterized LOC120099367 Neighboring gene protein phosphatase 1 regulatory subunit 3F Neighboring gene ribosomal protein L3, pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NFAT protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of CD4-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of CD4-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of T cell anergy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of T cell tolerance induction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial blood-brain barrier IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of immature T cell proliferation in thymus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of isotype switching to IgE isotypes ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myeloid cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of CREB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T-helper 17 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of chronic inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of histone deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of isotype switching to IgE isotypes ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell anergy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell tolerance induction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of immature T cell proliferation in thymus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-4 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peripheral T cell tolerance induction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transforming growth factor beta1 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of T cell anergy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of immunoglobulin production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of isotype switching to IgG isotypes ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to radiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to rapamycin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tolerance induction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tolerance induction to self antigen ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transforming growth factor beta1 production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108250.1NP_001101720.1  forkhead box protein P3

    See identical proteins and their annotated locations for NP_001101720.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474078
    UniProtKB/TrEMBL
    D3ZKI1, D4Q8I1
    Related
    ENSRNOP00000015641.5, ENSRNOT00000015641.7
    Conserved Domains (3) summary
    PHA03247
    Location:1137
    PHA03247; large tegument protein UL36; Provisional
    pfam16159
    Location:193260
    FOXP-CC; FOXP coiled-coil domain
    cd20066
    Location:337417
    FH_FOXP3; Forkhead (FH) domain found in Forkhead box protein P3 (FOXP3) and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051356.1 Reference mRatBN7.2 Primary Assembly

    Range
    14908494..14924994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099794.1XP_038955722.1  forkhead box protein P3 isoform X1

    Related
    ENSRNOP00000073801.1, ENSRNOT00000077391.2
    Conserved Domains (2) summary
    pfam16159
    Location:221288
    FOXP-CC; FOXP coiled-coil domain
    cd20066
    Location:365445
    FH_FOXP3; Forkhead (FH) domain found in Forkhead box protein P3 (FOXP3) and similar proteins
  2. XM_039099795.1XP_038955723.1  forkhead box protein P3 isoform X2

    Related
    ENSRNOP00000071307.1, ENSRNOT00000091146.2
    Conserved Domains (1) summary
    pfam16159
    Location:221288
    FOXP-CC; FOXP coiled-coil domain

RNA

  1. XR_005497985.1 RNA Sequence