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Ifna15 interferon alpha 15 [ Mus musculus (house mouse) ]

Gene ID: 242517, updated on 26-Sep-2022

Summary

Official Symbol
Ifna15provided by MGI
Official Full Name
interferon alpha 15provided by MGI
Primary source
MGI:MGI:3649418
See related
Ensembl:ENSMUSG00000096011 AllianceGenome:MGI:3649418
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ifnaa; If1ai1; Gm12597; MuIFN-alpha-A
Summary
Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Crimean-Congo hemorrhagic fever; common cold; hepatitis B; liver disease (multiple); and sarcoidosis. Orthologous to several human genes including IFNA4 (interferon alpha 4) and IFNA7 (interferon alpha 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See Ifna15 in Genome Data Viewer
Location:
4; 4 C4
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (88475910..88476482, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (88557673..88558245, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene focadhesin Neighboring gene 3-hydroxyacyl-CoA dehydratase 4 Neighboring gene interferon beta 1, fibroblast Neighboring gene interferon alpha gene, pseudogene 1 Neighboring gene interferon alpha 14

Genomic regions, transcripts, and products

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables type I interferon receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in T cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in humoral immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in natural killer cell activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interferon alpha 15
Names
interferon 1ai1
novel interferon alpha (Ifna) family member

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_206870.1NP_996753.1  interferon alpha 15 precursor

    See identical proteins and their annotated locations for NP_996753.1

    Status: PROVISIONAL

    Source sequence(s)
    M28587
    Consensus CDS
    CCDS18319.1
    UniProtKB/TrEMBL
    Q61718
    Related
    ENSMUSP00000099873.2, ENSMUST00000102809.2
    Conserved Domains (1) summary
    pfam00143
    Location:26185
    Interferon; Interferon alpha/beta domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    88475910..88476482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)