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Il4 interleukin 4 [ Mus musculus (house mouse) ]

Gene ID: 16189, updated on 25-Jan-2022

Summary

Official Symbol
Il4provided by MGI
Official Full Name
interleukin 4provided by MGI
Primary source
MGI:MGI:96556
See related
Ensembl:ENSMUSG00000000869 AllianceGenome:MGI:96556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il-4; BSF-1
Summary
Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Il4 in Genome Data Viewer
Location:
11 B1.3; 11 31.97 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53503287..53509492, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53612460..53618665, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (53425962..53432167, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene septin 8 Neighboring gene cyclin-like Neighboring gene RIKEN cDNA A430108G06 gene Neighboring gene kinesin family member 3A Neighboring gene origin of replication in Il13 Neighboring gene interleukin 13 Neighboring gene ribosomal protein S2, pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables interleukin-4 receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in B cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within B cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T-helper 1 cell lineage commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in T-helper 2 cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within T-helper 2 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of Janus kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response in mucosa IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response in mucosa IDA
Inferred from Direct Assay
more info
PubMed 
involved_in macrophage activation ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in myeloid dendritic cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T-helper 17 cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of T-helper 17 cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of acute inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chronic inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of chronic inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of complement-dependent cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of complement-dependent cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of white fat cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuroinflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MHC class II biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of MHC class II biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of amyloid-beta clearance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of amyloid-beta clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular respiration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of defense response to virus by host IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of eosinophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of eosinophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of immunoglobulin production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-10 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-13 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of interleukin-13 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of isotype switching to IgE isotypes IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of isotype switching to IgE isotypes IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of isotype switching to IgG isotypes IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mast cell degranulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of mast cell degranulation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mononuclear cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of mononuclear cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of myoblast fusion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of myoblast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor-mediated endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of proton transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-4
Names
B-cell IgG differentiation factor
B-cell growth factor 1
B-cell stimulatory factor 1
IGG1 induction factor
lymphocyte stimulatory factor 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021283.2NP_067258.1  interleukin-4 precursor

    See identical proteins and their annotated locations for NP_067258.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    BC027514, M25892
    Consensus CDS
    CCDS24682.1
    UniProtKB/Swiss-Prot
    P07750
    Related
    ENSMUSP00000000889.7, ENSMUST00000000889.7
    Conserved Domains (1) summary
    smart00190
    Location:1140
    IL4_13; Interleukins 4 and 13

RNA

  1. NR_027491.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AA199406, BC027514, BX529138
    Related
    ENSMUST00000150568.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    53503287..53509492 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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