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Items: 1 to 20 of 128205

1.
Full record GDS6248

Diet-induced obesity model: liver

Analysis of livers of C57BL/6J mice fed a high fat diet for up to 24 weeks. Significant body weight gain was observed after 4 weeks. Results provide insight into the effect of high fat diets on metabolism in the liver.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 protocol, 9 time sets
Platform:
GPL6887
Series:
GSE39549
51 Samples
Download data
2.
Full record GDS6247

Diet-induced obesity model: white adipose tissue

Analysis of epididymal and mesenteric white adipose tissues (WAT) of mice fed a high fat diet for up to 24 weeks. Excessive fat accumulation was evident in visceral WAT depots after 4 weeks. Results provide insight into the molecular events that occur during the development of diet-induced obesity.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 5 time, 2 tissue sets
Platform:
GPL6887
Series:
GSE39549
40 Samples
Download data
3.
Full record GDS6176

Caspase-1 deficiency effect on lipid-loaded intestines

Analysis of the epithelial layer of intestine from Casp1-null, C57BL/6 males 2 hours after an oral lipid bolus. Caspase-1 activates the proinflammatory cytokines IL-1β and IL-18. These results, together with those from GDS4922, provide insight into the role of caspase-1 in lipid metabolism.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 3 tissue sets
Platform:
GPL11533
Series:
GSE32515
18 Samples
Download data: CEL
4.
Full record GDS6000

High-fat diet effect on brown adipose tissue development

Analysis of interscapular brown adipose tissues from mice fed a high fat diet for up to 24 weeks. Results compared to those from epididymal white adipose tissues (GDS6247) in order to provide insight into the effect of high-fat diets on the development of brown and white adipose tissues.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 6 time sets
Platform:
GPL6887
Series:
GSE64718
33 Samples
Download data
DataSet
Accession:
GDS6000
ID:
6000
5.
Full record GDS5881

Nebulin deficiency effect on the soleus

Analysis of soleus muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE70213
12 Samples
Download data: CEL
6.
Full record GDS5880

Nebulin deficiency effect on the quadriceps

Analysis of quadriceps muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE70213
12 Samples
Download data: CEL
7.
Full record GDS5824

Short-term high fat diet effect on epididymal adipose fractions: time course

Analysis of primary adipocytes from epididymis of C57BL/6J males fed a 60% high fat diet (HFD) for up to 7 days to induce obesity. Results provide insight into the molecular mechanisms underlying insulin resistance in adipose tissues during early obesity.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol, 3 time, 2 tissue sets
Platform:
GPL6246
Series:
GSE65557
18 Samples
Download data: CEL
8.
Full record GDS5808

Type I angiotensin II receptor antagonist valsartan effect on mitral regurgitation males: left atria

Analysis of left atria of mitral regurgitation (MR) males treated with valsartan one week before surgery and then daily after surgery. Valsartan is a type I angiotensin II receptor blocker. Results provide insight into molecular mechanisms underlying atrial myocardial remodeling in MR subjects.
Organism:
Sus scrofa
Type:
Expression profiling by array, count, 2 agent, 2 stress sets
Platform:
GPL3533
Series:
GSE43072
6 Samples
Download data: CEL
DataSet
Accession:
GDS5808
ID:
5808
9.
Full record GDS5673

Glucagon effect on hepatocytes deficient in lysine acetyltransferase 2B or WD repeat-containing protein 5

Analysis of C57BL6/J primary hepatocytes depleted of either lysine acetyltransferase 2B (KAT2B) or WD repeat-containing protein 5 (WDR5) via shRNA knockdown, then stimulated with glucagon for 90 minutes. Results provide insight into the roles of KAT2B and WDR5 in hepatic gluconeogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 3 genotype/variation sets
Platform:
GPL6246
Series:
GSE47179
10 Samples
Download data: CEL, CHP
10.
Full record GDS5654

Subcutaneous and visceral adipose tissues

Analysis of adipose tissue from two subcutaneous depots (inguinal and axillary) and two visceral depots (epididymal and mesenteric) from age-matched, C57Bl/6 males. SubQ and VISC represent two broad categories of obesity. Results provide insight into fat depot-specific molecular profiles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 other, 2 tissue sets
Platform:
GPL8321
Series:
GSE53307
12 Samples
Download data: CEL
11.
Full record GDS5651

DNA methyltransferase inhibitor 5-Aza-2’deoxycytidine effect on partially-ligated left carotid artery

Analysis of arteries from C57BL/6 males pretreated with DNMT inhibitor 5Aza for 2 wk, then subjected to partial carotid ligation (PCL) and continued 5Aza treatment for 1 wk after ligation. PCL induces disturbed blood flow. Results provide insight into molecular basis of atherosclerosis development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 protocol, 2 tissue sets
Platform:
GPL6887
Series:
GSE56143
12 Samples
Download data
12.
Full record GDS5648

Chronic high-calorie diet effect on Kras-driven lung tumors

Analysis of lung tumors isolated from mice that develop KRAS-driven lung tumors. The KrasG12D mice were fed a high-calorie diet (HCD) starting 12 wk before tumor induction; tumors were collected 11 wk after tumor induction. Results provide insight into HCD effects on KRAS-driven lung tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 growth protocol sets
Platform:
GPL6887
Series:
GSE56260
11 Samples
Download data
13.
Full record GDS5520

Rosiglitazone effect on adipose progenitor cells

Analysis of adipose progenitor cells from animals fed a diet supplemented with rosiglitazone (ROS) for 2 months. ROS is a thiazolidinedione antidiabetic drug. Results provide insight into the effect of chronic ROS administration on the stem cell properties of adipose progenitor cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL6887
Series:
GSE30116
6 Samples
Download data
14.
Full record GDS5473

Short-term fasting effect on skeletal muscle: time course

Analysis of skeletal muscle biopsies collected at 1.5, 4, 10, and 24hr post-meal time from healthy young men subjected to a 24hr fast. Results provide insight into the molecular mechanisms underlying metabolic adaptation to fasting in healthy humans.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 12 individual, 4 time sets
Platform:
GPL10558
Series:
GSE55924
48 Samples
Download data
DataSet
Accession:
GDS5473
ID:
5473
15.
Full record GDS5469

Left ventricle myocardium from MerCreMer model of transient cardiomyopathy: time course

Temporal analysis of left ventricle myocardium from the MCM model of cardiomyopathy. Transient cardiomyopathy develops in this model after 5 day exposure to tamoxifen, with peak heart failure (HF) at day 10, and resolved HF at day 28. Results provide insight into the molecular basis of evolving HF.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 disease state, 5 protocol, 5 time sets
Platform:
GPL6885
Series:
GSE54681
19 Samples
Download data
16.
Full record GDS5435

Dietary palatinose effect on liver

Analysis of liver from C57Bl/6J males fed isocaloric diets containing sucrose or palatinose. Sucrose is a high glycemic index (GI) sugar; palatinose is a low GI sugar. Results provide insight into molecular mechanisms underlying the role of sucrose in the development of non-alcoholic fatty liver.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL6885
Series:
GSE54723
14 Samples
Download data
DataSet
Accession:
GDS5435
ID:
5435
17.
Full record GDS5425

Monoacylglycerol acyltransferase 1 deficiency effect on high-fat diet fed mice: liver

Analysis of liver from diet-induced obese males depleted for monoacylglycerol acyltransferase 1 (Mogat1) via intraperitoneal injections of antisense oligonucleotide directed against Mogat1. Results provide insight into the role of Mogat1 in the development of nonalcoholic steatohepatitis (NASH).
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6887
Series:
GSE60349
8 Samples
Download data
18.
Full record GDS5390

Whey protein hydrolysate diet effect on exercised epitrochlearis muscle

Analysis of epitrochlearis muscle from males exercised for 2hr then fed a whey protein hydrolysate (WPH) diet or a control diet with an identical amino acid composition (AAM). Results provide insight into the molecular basis of the greater post-exercise muscle protein synthesis in the WPH group.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 protocol sets
Platform:
GPL1355
Series:
GSE49486
8 Samples
Download data: CEL
DataSet
Accession:
GDS5390
ID:
5390
19.
Full record GDS5378

Peroxisome proliferator-activated receptor δ (PPARδ) activation effect on cultured myotubes

Analysis of musculus obliquus internus myotubes treated with PPARδ agonist GW501516 for 96hrs. PPARs regulate lipid utilization and storage. PPARδ is the most abundant PPAR subtype in skeletal muscle. Results provide insight into the molecular effects of PPARδ activation on myotubes.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 4 individual sets
Platform:
GPL6244
Series:
GSE40789
8 Samples
Download data: CEL
DataSet
Accession:
GDS5378
ID:
5378
20.
Full record GDS5377

Folate deficiency effect on methylenetetrahydrofolate reductase MTHFR+/- intestinal neoplasia model: duodenum

Analysis of intestine from MTHFR+/- BALB/c mice fed a low folate diet (0.3mg/kg) for 1 yr. The MTHFR C677T polymorphism is associated with risk for colorectal cancer. Results provide insight into mechanisms underlying the impact of folate and MTHFR deficiency on tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL6246
Series:
GSE34011
8 Samples
Download data: CEL
DataSet
Accession:
GDS5377
ID:
5377
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db=gds|term=human[organism]%20AND%20smok*%20OR%20diet|query=1|qty=262|blobid=NCID_1_54206367_130.14.18.34_9001_1513365125_1051744084_0MetA0_S_MegaStore_F_1|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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