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Items: 1 to 20 of 4348

1.
Full record GDS6248

Diet-induced obesity model: liver

Analysis of livers of C57BL/6J mice fed a high fat diet for up to 24 weeks. Significant body weight gain was observed after 4 weeks. Results provide insight into the effect of high fat diets on metabolism in the liver.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 protocol, 9 time sets
Platform:
GPL6887
Series:
GSE39549
51 Samples
Download data
2.
Full record GDS6247

Diet-induced obesity model: white adipose tissue

Analysis of epididymal and mesenteric white adipose tissues (WAT) of mice fed a high fat diet for up to 24 weeks. Excessive fat accumulation was evident in visceral WAT depots after 4 weeks. Results provide insight into the molecular events that occur during the development of diet-induced obesity.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 5 time, 2 tissue sets
Platform:
GPL6887
Series:
GSE39549
40 Samples
Download data
3.
Full record GDS6177

Acute alcohol consumption effect on whole blood (control group): time course

Analysis of blood from subjects administered orange juice w/o alcohol. Blood collected at time points corresponding to collection times for the alcohol group in GDS4938. These results, together with those from GDS4938, provide insight into molecular response of blood during acute ethanol exposure.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 individual, 2 protocol, 5 time sets
Platform:
GPL570
Series:
GSE20489
25 Samples
Download data: CEL
4.
Full record GDS6176

Caspase-1 deficiency effect on lipid-loaded intestines

Analysis of the epithelial layer of intestine from Casp1-null, C57BL/6 males 2 hours after an oral lipid bolus. Caspase-1 activates the proinflammatory cytokines IL-1β and IL-18. These results, together with those from GDS4922, provide insight into the role of caspase-1 in lipid metabolism.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 3 tissue sets
Platform:
GPL11533
Series:
GSE32515
18 Samples
Download data: CEL
5.
Full record GDS6100

MicroRNA-135b overexpression effect on prostate cancer cell line: time course

Analysis of LNCaP prostate cancer (PCa) cells overexpressing miRNA-135b for up to 36 hours. LNCaP cells express the androgen receptor (AR). MiRNA-135b overexpression in AR+ PCa cells results in slower growth compared to AR knockdown. Results provide insight into the basis of this slower growth.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 protocol, 3 time sets
Platform:
GPL10558
Series:
GSE57820
12 Samples
Download data
6.
Full record GDS6083

Chronic lymphocytic leukemia cells response to the neutralization of inhibitor of apoptosis proteins

Analysis of chronic lymphocytic leukemia (CLL) cells treated with BV6, a Smac mimetic. CLL is characterized by B-lymphocyte accumulation, which is attributed to defective cell death. Inhibitor of apoptosis (IAP) proteins are highly expressed in CLL cells. Smac binds to and inhibits IAP proteins.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 4 genotype/variation, 4 individual, 2 other, 2 time sets
Platform:
GPL570
Series:
GSE62533
12 Samples
Download data: CEL
DataSet
Accession:
GDS6083
ID:
6083
7.
Full record GDS6082

Sendai virus infection effect on monocytic cell line: dose response

Analysis of U937 monocytic cells infected at multiplicities of infection of 0.0002 and 0.02 with the Sendai virus. Results provide insight into the differences between the innate immune response of cells infected with a low and high concentration of virus.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 dose, 2 infection sets
Platform:
GPL10558
Series:
GSE67198
11 Samples
Download data
8.
Full record GDS6064

Arthritic tarsal joints induced by collagen: time course

Analysis of tarsal joints for up to 4 weeks following treatment with collagen to induce arthritis. Collagen induced arthritis is a model for rheumatoid arthritis. Results provide insight into the molecular events underlying the inflammation and bone remodeling that occurs in inflammatory arthritis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 5 time sets
Platform:
GPL6246
Series:
GSE61140
15 Samples
Download data: CEL
9.
Full record GDS6063

Influenza A effect on plasmacytoid dendritic cells

Analysis of primary plasmacytoid dendritic cells (pDC) exposed to influenza A for 8 hours ex vivo. pDCs are vital to antiviral defense, directing immune responses via secretion of interferon-alpha. Results provide insight into the regulation of the response of pDC to viral pathogens.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 5 individual, 2 infection sets
Platform:
GPL10558
Series:
GSE68849
10 Samples
Download data
10.
Full record GDS6016

Transcription factor engrailed-2 loss-of-function model of autism spectrum disorder: hippocampus

Analysis of hippocampal samples from engrailed-2 (En2) mutant adults. The En2-/- animals are a model for autism spectrum disorder (ASD). The hippocampus is a brain area profoundly affected in ASD patients. Results provide insight into molecular mechanisms underlying ASD-related neuropathology.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL7202
Series:
GSE51612
6 Samples
Download data: TXT
11.
Full record GDS6010

Influenza virus H5N1 infection of U251 astrocyte cell line: time course

Analysis of U251 astrocyte cells infected with the influenza H5N1 virus for up to 24 hours. Results provide insight into the immune response of astrocytes to H5N1 infection.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 infection, 3 time sets
Platform:
GPL6480
Series:
GSE66597
18 Samples
Download data: TXT
12.
Full record GDS6000

High-fat diet effect on brown adipose tissue development

Analysis of interscapular brown adipose tissues from mice fed a high fat diet for up to 24 weeks. Results compared to those from epididymal white adipose tissues (GDS6247) in order to provide insight into the effect of high-fat diets on the development of brown and white adipose tissues.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 6 time sets
Platform:
GPL6887
Series:
GSE64718
33 Samples
Download data
DataSet
Accession:
GDS6000
ID:
6000
13.
Full record GDS5948

Zipper-interacting protein kinase deficiency effect on coronary artery smooth muscle cells in vitro

Analysis of cultured vascular smooth muscle cells following knockdown of zipper-interacting protein kinase (ZIPK). ZIPK is phosphorylated and activated by Rho-associated kinase 1 (ROCK1). These results, together with those from GDS5659, provide further insight into ROCK1 and ZIPK functions.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6244
Series:
GSE56819
6 Samples
Download data: CEL
14.
Full record GDS5914

YAP transcriptional regulator depletion effect on endothelial cells

Analysis of umbilical vein endothelial HUVEC cells depleted for the transcriptional regulator YAP. YAP binds to the SH3 domain of the transcriptional activator Yes. Results provide insight into the role of YAP in endothelial cell proliferation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent, 2 protocol sets
Platform:
GPL6244
Series:
GSE61989
12 Samples
Download data: CEL
15.
Full record GDS5913

SRPIN803 small molecule inhibitor of SRPK1 effect on retinal pigment epithelial cell line

Analysis of retinal pigment epithelial ARPE-19 cells treated with SRPIN803, a small molecule inhibitor of serine-arginine protein kinase 1 SRPK1. SRPK1 inhibition prevents pathological angiogenesis. Results provide insight into the molecular mechanisms underlying the inhibitory activity of SRPIN803.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL570
Series:
GSE62947
6 Samples
Download data: CEL
DataSet
Accession:
GDS5913
ID:
5913
16.
Full record GDS5881

Nebulin deficiency effect on the soleus

Analysis of soleus muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE70213
12 Samples
Download data: CEL
17.
Full record GDS5880

Nebulin deficiency effect on the quadriceps

Analysis of quadriceps muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE70213
12 Samples
Download data: CEL
18.
Full record GDS5879

Pulmonary CDC11c+ cells from young and middle-age animals

Analysis of pulmonary CDC11c+ cells from 6-8 week and 10-13 month old C57BL/6 animals. CDC11c+ cells are key modulators of the immune response in the lung. Results provide insight into molecular mechanisms underlying the decline in immune function associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL6885
Series:
GSE71868
8 Samples
Download data
19.
Full record GDS5826

Multiple myeloma cell lines with acquired resistance to chemotherapeutic agent carfilzomib

Analysis of proteasome inhibitor carfilzomib-resistant multiple myeloma (MM) cell lines KMS-11/Cfz and KMS-34/Cfz, after 1 week of growth in the absence of carfilzomib. Results provide insight into the molecular mechanisms underlying the acquisition of proteasome inhibitor resistance in MM.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 cell line, 2 cell type sets
Platform:
GPL570
Series:
GSE69078
12 Samples
Download data: CEL
20.
Full record GDS5825

Interleukin-1α deficiency effect on injured spinal cord

Analysis of spinal cord segment from interleukin (IL)-1α -/- and IL-1β -/- C57BL/6 adults 24 hrs after spinal cord injury (SCI). IL-1α and IL-1β belong to a family of cytokines playing a key role in neurodegeneration. Results provide insight into the role of IL-1α in the neuropathology of SCI.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL6246
Series:
GSE70302
12 Samples
Download data: CEL
DataSet
Accession:
GDS5825
ID:
5825
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