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Items: 1 to 20 of 140152

1.
Full record GDS6177

Acute alcohol consumption effect on whole blood (control group): time course

Analysis of blood from subjects administered orange juice w/o alcohol. Blood collected at time points corresponding to collection times for the alcohol group in GDS4938. These results, together with those from GDS4938, provide insight into molecular response of blood during acute ethanol exposure.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 individual, 2 protocol, 5 time sets
Platform:
GPL570
Series:
GSE20489
25 Samples
Download data: CEL
2.
Full record GDS6083

Chronic lymphocytic leukemia cells response to the neutralization of inhibitor of apoptosis proteins

Analysis of chronic lymphocytic leukemia (CLL) cells treated with BV6, a Smac mimetic. CLL is characterized by B-lymphocyte accumulation, which is attributed to defective cell death. Inhibitor of apoptosis (IAP) proteins are highly expressed in CLL cells. Smac binds to and inhibits IAP proteins.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 4 genotype/variation, 4 individual, 2 other, 2 time sets
Platform:
GPL570
Series:
GSE62533
12 Samples
Download data: CEL
DataSet
Accession:
GDS6083
ID:
6083
3.
Full record GDS5913

SRPIN803 small molecule inhibitor of SRPK1 effect on retinal pigment epithelial cell line

Analysis of retinal pigment epithelial ARPE-19 cells treated with SRPIN803, a small molecule inhibitor of serine-arginine protein kinase 1 SRPK1. SRPK1 inhibition prevents pathological angiogenesis. Results provide insight into the molecular mechanisms underlying the inhibitory activity of SRPIN803.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL570
Series:
GSE62947
6 Samples
Download data: CEL
DataSet
Accession:
GDS5913
ID:
5913
4.
Full record GDS5826

Multiple myeloma cell lines with acquired resistance to chemotherapeutic agent carfilzomib

Analysis of proteasome inhibitor carfilzomib-resistant multiple myeloma (MM) cell lines KMS-11/Cfz and KMS-34/Cfz, after 1 week of growth in the absence of carfilzomib. Results provide insight into the molecular mechanisms underlying the acquisition of proteasome inhibitor resistance in MM.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 cell line, 2 cell type sets
Platform:
GPL570
Series:
GSE69078
12 Samples
Download data: CEL
5.
Full record GDS5817

Interleukin 17A effect on monocyte-derived dendritic cells

Analysis of in vitro-generated dendritic cells (DCs) cultured with interleukin 17A (IL-17A) in the absence or presence of interferon-γ. IL-17A is involved in chronic inflammatory diseases. Results provide insight into the impact of IL-17A on DCs and the role of these DCs in inflammatory disease.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 protocol, 2 time sets
Platform:
GPL570
Series:
GSE53163
9 Samples
Download data: CEL
6.
Full record GDS5804

PI3K/mTOR Inhibitor NVP-BEZ235 and taxotere effects on prostate cancer xenograft tumors

Analysis of DU145 xenograft tumors in NOD/SCID mice treated with NVP-BEZ235, taxotere, or both. NVP-BEZ235 targets prostate cancer progenitor cells. Taxotere targets the bulk tumor. Results provide insight into potential biomarkers associated with cancer stem cells in these xenograft tumors.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 agent sets
Platform:
GPL570
Series:
GSE49232
4 Samples
Download data: CEL
DataSet
Accession:
GDS5804
ID:
5804
7.
Full record GDS5672

Anti-VEGF and Anti-Notch treatment effect on U87 glioblastoma xenograft tumors [HG-U133_Plus_2]

Analysis of U87 human xenograft tumors (in BALB/c SCID mouse host) treated with antiangiogenic agents bevacizumab (anti-VEGF) and dibenzazepine (anti-Notch). The tumors include mouse host stroma. Results, together with those from GDS5678, provide insight into molecular basis of tumor angiogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 agent sets
Platform:
GPL570
Series:
GSE39223
9 Samples
Download data: CEL
8.
Full record GDS5633

Peroxisome proliferator-activated receptor β/δ agonist and hypoxia effects on umbilical vein endothelial cells

Analysis of HUVECs stimulated with two important angiogenic stimuli: peroxisome proliferator-activated receptor (PPAR) β/δ agonist and hypoxia. Results provide insight into possible synergistic molecular interactions between the PPAR β/δ and hypoxia-inducible factor (HIF) 1 signaling pathways.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 stress sets
Platform:
GPL570
Series:
GSE50378
4 Samples
Download data: CEL
9.
Full record GDS5632

In vitro myoblast differentiation: time course

Analysis of myoblasts isolated from a 7 year-old male and cultured in low-serum medium to stimulate myogenic differentiation for up 15 days. Results provide insight into the molecular mechanisms underlying myogenic differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 protocol, 4 time sets
Platform:
GPL570
Series:
GSE55034
4 Samples
Download data: CEL, CHP
10.
Full record GDS5614

All-trans retinoic acid effect on HL60 myeloid cells overexpressing ecotropic virus integration site 1

Analysis of EVI1-overexpressing HL60 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE66837
12 Samples
Download data: CEL
11.
Full record GDS5613

All-trans retinoic acid effect on U937 myeloid cells overexpressing ecotropic virus integration site 1

Analysis of EVI1-overexpressing U937 myeloid cells treated with ATRA. EVI1 overexpression is associated with poor prognosis in myeloid leukemias; ATRA is a myeloid differentiation inducing agent. Results provide insight into the potential interplay between EVI1 and ATRA in myeloid cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE66854
12 Samples
Download data: CEL
12.
Full record GDS5607

A 3-D ex vivo model of oral wound healing: primary gingival fibroblasts

Analysis of gingival fibroblasts populating sponge-type or gel-type collagen scaffolds loaded with platelet-derived growth factor-BB. Collagen scaffolds augment oral soft tissue to support wound repair. Results provide insight into molecular basis of cell population dynamics of collagen scaffolds.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 growth protocol sets
Platform:
GPL570
Series:
GSE61314
4 Samples
Download data: CEL, CHP
13.
Full record GDS5443

Human and chimpanzee TS12KOS vector-generated induced pluripotent stem cells

Analysis of chimpanzee iPSCs generated from blood cells using Sendai virus vector TS12KOS which carries reprogramming factors KLF4, OCT3/4, and SOX2. TS12KOS was also used to establish human iPSCs from fibroblasts. Results examine differentially expressed genes between human and chimpanzee iPSCs.
Organism:
Pan troglodytes; Homo sapiens
Type:
Expression profiling by array, transformed count, 2 cell type, 5 individual, 2 species sets
Platform:
GPL570
Series:
GSE62572
7 Samples
Download data: CEL
14.
Full record GDS5430

Ethanol effect on lymphoblastoid cell lines from alcoholics

Analysis of lymphoblastoid cell lines (LCLs), obtained from alcoholics, after treatment with ethanol in vitro. Results provide insight into the feasibility of using LCLs to study the molecular consequences of exposure to alcohol.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 disease state, 2 gender, 42 individual sets
Platform:
GPL570
Series:
GSE52553
84 Samples
Download data: CEL, CHP
15.
Full record GDS5426

Hutchinson Gilford Progeria Syndrome cell line response to oncogenic challenge

Analysis of skin fibroblasts from Hutchinson Gilford Progeria Syndrome (HGPS) patients challenged by retroviral introduction of telomerase reverse transcriptase (TERT), V12-HRAS and SV40 large and small T antigens. Results provide insight into molecular basis of transformation resistance in HGPS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state, 4 individual, 2 protocol sets
Platform:
GPL570
Series:
GSE60518
8 Samples
Download data: CEL
16.
Full record GDS5420

Psoriasis response to brodalumab: dose response and time course

Analysis of non-lesional and lesional psoriatic skins for up to 43 days following treatment with various doses of brodalumab, a human IgG2 mAb that selectively binds and blocks signaling through IL-17RA. Results provide insight into the molecular effect of blocking IL-17 signaling in psoriatic skin.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent, 4 dose, 25 individual, 4 time, 2 tissue sets
Platform:
GPL570
Series:
GSE53552
99 Samples
Download data: CEL
DataSet
Accession:
GDS5420
ID:
5420
17.
Full record GDS5418

Glucose effect on steroid receptor coactivator 1 deficient-A549 lung cancer epithelial cell line

Analysis of highly glycolytic A549 lung cancer cells depleted for steroid receptor coactivator SRC-1 and grown in the absence of glucose. SRC-1 promotes gluconeogenesis and glycemia. Results provide insight into the role of SRC-1 in glycolytic cancer cells undergoing glucose deprivation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL570
Series:
GSE56843
8 Samples
Download data: CEL
18.
Full record GDS5408

H1 and H9 embryonic stem cell lines undergoing differentiation

Analysis of undifferentiated H1 and H9 embryonic stem cell (ESC) lines and their differentiated embryoid bodies (EB). Result provide insight into those genes consistently altered during ESC differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 cell line, 2 protocol sets
Platform:
GPL570
Series:
GSE54186
8 Samples
Download data: CEL
19.
Full record GDS5406

Imatinib mesylate effect on EOL-1 eosinophilic leukemia cell line

Analysis of EOL-1 cells treated with imatinib mesylate (1uM, 6h). EOL-1 cells carry the platelet derived growth factor receptor α (PDGFRA)/FIP1L1 fusion and exhibit constitutive PDGFRA activation. Results provide insight into the molecular effects of inhibiting PDGFRA signaling by imatinib.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL570
Series:
GSE53633
4 Samples
Download data: CEL
DataSet
Accession:
GDS5406
ID:
5406
20.
Full record GDS5405

Imatinib mesylate effect on patient peripheral T-cell lymphomas, not otherwise specified (PTCL/NOS) cells

Analysis of patient PTCL/NOS cells treated with imatinib mesylate (1uM, 6h). PTCL/NOS tumors are characterized by aberrant expression of platelet-derived growth factor receptor α (PDGFRA). Results provide insight into the molecular effects of inhibiting PDGFRA signaling by imatinib.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL570
Series:
GSE53633
4 Samples
Download data: CEL
DataSet
Accession:
GDS5405
ID:
5405
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