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Items: 1 to 20 of 75390

1.
Full record GDS6248

Diet-induced obesity model: liver

Analysis of livers of C57BL/6J mice fed a high fat diet for up to 24 weeks. Significant body weight gain was observed after 4 weeks. Results provide insight into the effect of high fat diets on metabolism in the liver.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 protocol, 9 time sets
Platform:
GPL6887
Series:
GSE39549
51 Samples
Download data
2.
Full record GDS6247

Diet-induced obesity model: white adipose tissue

Analysis of epididymal and mesenteric white adipose tissues (WAT) of mice fed a high fat diet for up to 24 weeks. Excessive fat accumulation was evident in visceral WAT depots after 4 weeks. Results provide insight into the molecular events that occur during the development of diet-induced obesity.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 5 time, 2 tissue sets
Platform:
GPL6887
Series:
GSE39549
40 Samples
Download data
3.
Full record GDS6176

Caspase-1 deficiency effect on lipid-loaded intestines

Analysis of the epithelial layer of intestine from Casp1-null, C57BL/6 males 2 hours after an oral lipid bolus. Caspase-1 activates the proinflammatory cytokines IL-1β and IL-18. These results, together with those from GDS4922, provide insight into the role of caspase-1 in lipid metabolism.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 3 tissue sets
Platform:
GPL11533
Series:
GSE32515
18 Samples
Download data: CEL
4.
Full record GDS6000

High-fat diet effect on brown adipose tissue development

Analysis of interscapular brown adipose tissues from mice fed a high fat diet for up to 24 weeks. Results compared to those from epididymal white adipose tissues (GDS6247) in order to provide insight into the effect of high-fat diets on the development of brown and white adipose tissues.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 6 time sets
Platform:
GPL6887
Series:
GSE64718
33 Samples
Download data
DataSet
Accession:
GDS6000
ID:
6000
5.
Full record GDS5881

Nebulin deficiency effect on the soleus

Analysis of soleus muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE70213
12 Samples
Download data: CEL
6.
Full record GDS5880

Nebulin deficiency effect on the quadriceps

Analysis of quadriceps muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE70213
12 Samples
Download data: CEL
7.
Full record GDS5824

Short-term high fat diet effect on epididymal adipose fractions: time course

Analysis of primary adipocytes from epididymis of C57BL/6J males fed a 60% high fat diet (HFD) for up to 7 days to induce obesity. Results provide insight into the molecular mechanisms underlying insulin resistance in adipose tissues during early obesity.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol, 3 time, 2 tissue sets
Platform:
GPL6246
Series:
GSE65557
18 Samples
Download data: CEL
8.
Full record GDS5808

Type I angiotensin II receptor antagonist valsartan effect on mitral regurgitation males: left atria

Analysis of left atria of mitral regurgitation (MR) males treated with valsartan one week before surgery and then daily after surgery. Valsartan is a type I angiotensin II receptor blocker. Results provide insight into molecular mechanisms underlying atrial myocardial remodeling in MR subjects.
Organism:
Sus scrofa
Type:
Expression profiling by array, count, 2 agent, 2 stress sets
Platform:
GPL3533
Series:
GSE43072
6 Samples
Download data: CEL
DataSet
Accession:
GDS5808
ID:
5808
9.
Full record GDS5673

Glucagon effect on hepatocytes deficient in lysine acetyltransferase 2B or WD repeat-containing protein 5

Analysis of C57BL6/J primary hepatocytes depleted of either lysine acetyltransferase 2B (KAT2B) or WD repeat-containing protein 5 (WDR5) via shRNA knockdown, then stimulated with glucagon for 90 minutes. Results provide insight into the roles of KAT2B and WDR5 in hepatic gluconeogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 3 genotype/variation sets
Platform:
GPL6246
Series:
GSE47179
10 Samples
Download data: CEL, CHP
10.
Full record GDS5654

Subcutaneous and visceral adipose tissues

Analysis of adipose tissue from two subcutaneous depots (inguinal and axillary) and two visceral depots (epididymal and mesenteric) from age-matched, C57Bl/6 males. SubQ and VISC represent two broad categories of obesity. Results provide insight into fat depot-specific molecular profiles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 other, 2 tissue sets
Platform:
GPL8321
Series:
GSE53307
12 Samples
Download data: CEL
11.
Full record GDS5651

DNA methyltransferase inhibitor 5-Aza-2’deoxycytidine effect on partially-ligated left carotid artery

Analysis of arteries from C57BL/6 males pretreated with DNMT inhibitor 5Aza for 2 wk, then subjected to partial carotid ligation (PCL) and continued 5Aza treatment for 1 wk after ligation. PCL induces disturbed blood flow. Results provide insight into molecular basis of atherosclerosis development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 protocol, 2 tissue sets
Platform:
GPL6887
Series:
GSE56143
12 Samples
Download data
12.
Full record GDS5648

Chronic high-calorie diet effect on Kras-driven lung tumors

Analysis of lung tumors isolated from mice that develop KRAS-driven lung tumors. The KrasG12D mice were fed a high-calorie diet (HCD) starting 12 wk before tumor induction; tumors were collected 11 wk after tumor induction. Results provide insight into HCD effects on KRAS-driven lung tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 growth protocol sets
Platform:
GPL6887
Series:
GSE56260
11 Samples
Download data
13.
Full record GDS5520

Rosiglitazone effect on adipose progenitor cells

Analysis of adipose progenitor cells from animals fed a diet supplemented with rosiglitazone (ROS) for 2 months. ROS is a thiazolidinedione antidiabetic drug. Results provide insight into the effect of chronic ROS administration on the stem cell properties of adipose progenitor cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL6887
Series:
GSE30116
6 Samples
Download data
14.
Full record GDS5469

Left ventricle myocardium from MerCreMer model of transient cardiomyopathy: time course

Temporal analysis of left ventricle myocardium from the MCM model of cardiomyopathy. Transient cardiomyopathy develops in this model after 5 day exposure to tamoxifen, with peak heart failure (HF) at day 10, and resolved HF at day 28. Results provide insight into the molecular basis of evolving HF.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 4 disease state, 5 protocol, 5 time sets
Platform:
GPL6885
Series:
GSE54681
19 Samples
Download data
15.
Full record GDS5438

Lung from cigarette smoke-related chronic obstructive pulmonary disease model: time course

Analysis of lung from cigarette smoke (CS)-treated C57BL/6N females at 4 and 6 months of age. Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD). Results provide insight into the molecular mechanisms underlying cigarette smoke-induced COPD.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 stress sets
Platform:
GPL6885
Series:
GSE52509
12 Samples
Download data
DataSet
Accession:
GDS5438
ID:
5438
16.
Full record GDS5435

Dietary palatinose effect on liver

Analysis of liver from C57Bl/6J males fed isocaloric diets containing sucrose or palatinose. Sucrose is a high glycemic index (GI) sugar; palatinose is a low GI sugar. Results provide insight into molecular mechanisms underlying the role of sucrose in the development of non-alcoholic fatty liver.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL6885
Series:
GSE54723
14 Samples
Download data
DataSet
Accession:
GDS5435
ID:
5435
17.
Full record GDS5425

Monoacylglycerol acyltransferase 1 deficiency effect on high-fat diet fed mice: liver

Analysis of liver from diet-induced obese males depleted for monoacylglycerol acyltransferase 1 (Mogat1) via intraperitoneal injections of antisense oligonucleotide directed against Mogat1. Results provide insight into the role of Mogat1 in the development of nonalcoholic steatohepatitis (NASH).
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6887
Series:
GSE60349
8 Samples
Download data
18.
Full record GDS5390

Whey protein hydrolysate diet effect on exercised epitrochlearis muscle

Analysis of epitrochlearis muscle from males exercised for 2hr then fed a whey protein hydrolysate (WPH) diet or a control diet with an identical amino acid composition (AAM). Results provide insight into the molecular basis of the greater post-exercise muscle protein synthesis in the WPH group.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 protocol sets
Platform:
GPL1355
Series:
GSE49486
8 Samples
Download data: CEL
DataSet
Accession:
GDS5390
ID:
5390
19.
Full record GDS5377

Folate deficiency effect on methylenetetrahydrofolate reductase MTHFR+/- intestinal neoplasia model: duodenum

Analysis of intestine from MTHFR+/- BALB/c mice fed a low folate diet (0.3mg/kg) for 1 yr. The MTHFR C677T polymorphism is associated with risk for colorectal cancer. Results provide insight into mechanisms underlying the impact of folate and MTHFR deficiency on tumorigenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL6246
Series:
GSE34011
8 Samples
Download data: CEL
DataSet
Accession:
GDS5377
ID:
5377
20.
Full record GDS5345

Dietary vitamin D3 supplementation effect on hippocampus: dose effect

Analysis of hippocampus from F344 rats fed dietary supplement of cholecalciferol (vitamin D3) at doses of 10,000, 1000 and 100 IU/kg diet for 18 weeks. Results provide insight into molecular mechanisms underlying vitamin D-mediated synaptic function enhancement.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 3 dose sets
Platform:
GPL6247
Series:
GSE61326
26 Samples
Download data: CEL
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db=gds|term=(smok*%20OR%20diet)%20AND%20(mammals[organism]%20NOT%20human[organism])|query=1|qty=48|blobid=NCID_1_19577094_130.14.22.215_9001_1501209683_843469765_0MetA0_S_MegaStore_F_1|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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